ArticleAmerican journal of physiology. Lung cellular and molecular physiology2013
Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.
Article in American journal of physiology. Lung cellular and molecular physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Dynamic measurement of airway surface liquid volume with anLab on a chip · 2024Article
- A predominately pulmonary activation of complement in a mouse model of severe COVID-19.bioRxiv : the preprint server for biology · 2024Article
- Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets.Respiratory research · 2023Article
- Comparison of the broncoalveolar lavage fluid proteomics between foals and adult horses.PloS one · 2023Article
- Urine Proteomics for Noninvasive Monitoring of Biomarkers in Bronchopulmonary Dysplasia.Neonatology · 2022Article
- Respiratory mucus as a virus-host range determinant.Trends in microbiology · 2021Review
- Article
- Airway Surface Liquid Has Innate Antiviral Activity That Is Reduced in Cystic Fibrosis.American journal of respiratory cell and molecular biology · 2020Article
- Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells.Journal of inflammation research · 2020Article
- Development of a comprehensive protein microarray for immunoglobulin E profiling in horses with severe asthma.Journal of veterinary internal medicine · 2019Article
- Enolase FromFrontiers in immunology · 2019Article
- Reaction products of hexamethylene diisocyanate vapors with "self" molecules in the airways of rabbits exposed via tracheostomy.Xenobiotica; the fate of foreign compounds in biological systems · 2018Article
- Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance.Respiratory research · 2018Article
- Extracellular Actin Is a Receptor forFrontiers in cellular and infection microbiology · 2018Article
- Aspf2 FromFrontiers in immunology · 2018Article
- Looking ahead: where to next for animal models of bronchopulmonary dysplasia?Cell and tissue research · 2017Review
- Analysis of nanoparticle-protein coronas formed in vitro between nanosized welding particles and nasal lavage proteins.Nanotoxicology · 2016Article
- Increased susceptibility to otitis media in a Splunc1-deficient mouse model.Disease models & mechanisms · 2015Article
- Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins.PloS one · 2015Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The airway mucosa and the alveolar surface form dynamic interfaces between the lung and the external environment. The epithelial cells lining these barriers elaborate a thin liquid layer containing secreted peptides and proteins that contribute to host defense and other functions. The goal of this study was to develop and apply methods to define the proteome of porcine lung lining liquid, in part, by leveraging the wealth of information in the Sus scrofa database of Ensembl gene, transcript, and protein model predictions. We developed an optimized workflow for detection of secreted proteins in porcine bronchoalveolar lavage (BAL) fluid and in methacholine-induced tracheal secretions [airway surface liquid (ASL)]. We detected 674 and 3,858 unique porcine-specific proteins in BAL and ASL, respectively. This proteome was composed of proteins representing a diverse range of molecular classes and biological processes, including host defense, molecular transport, cell communication, cytoskeletal, and metabolic functions. Specifically, we detected a significant number of secreted proteins with known or predicted roles in innate and adaptive immunity, microbial killing, or other aspects of host defense. In greatly expanding the known proteome of the lung lining fluid in the pig, this study provides a valuable resource for future studies using this important animal model of pulmonary physiology and disease.
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