ArticleApplied and environmental microbiology2013
The highly autoaggregative and adhesive phenotype of the vaginal Lactobacillus plantarum strain CMPG5300 is sortase dependent.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Prospecting and characterization of potential probiotic lactobacilli from animal gut and food sources.Scientific reports · 2026Article
- The Effect of Probiotics on Preterm Birth Rates in Pregnant Women After a Threatened Preterm Birth Episode (The PROPEV Trial).Biomedicines · 2025Article
- Single-Molecule Approach to 16S rRNA for Vaginal Microbiome Signatures in Response to Metronidazole Treatment.Microbiology spectrum · 2023Article
- Adhesion and Anti-Adhesion Abilities of Potentially Probiotic Lactic Acid Bacteria and Biofilm Eradication of Honeybee (Molecules (Basel, Switzerland) · 2022Article
- Microbial Interaction between Lactiplantibacillus plantarum and Saccharomyces cerevisiae: Transcriptome Level Mechanism of Cell-Cell Antagonism.Microbiology spectrum · 2022Article
- Spatiotemporal bio-shielding of bacteria through consolidated geometrical structuring.NPJ biofilms and microbiomes · 2022Article
- The Antibiofilm Role of Biotics Family in Vaginal Fungal Infections.Frontiers in microbiology · 2022Review
- Bistable auto-aggregation phenotype in Lactiplantibacillus plantarum emerges after cultivation in in vitro colonic microbiota.BMC microbiology · 2021Article
- Effect ofAntibiotics (Basel, Switzerland) · 2021Article
- Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections.Probiotics and antimicrobial proteins · 2021Article
- Selection and screening of bacteria from African nightcrawler, Eudrilus eugeniae (Kinberg, 1867) as potential probiotics in aquaculture.World journal of microbiology & biotechnology · 2020Article
- Putative Adhesion Factors in Vaginal Lactobacillus gasseri DSM 14869: Functional Characterization.Applied and environmental microbiology · 2019Article
- Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG.Scientific reports · 2019Article
- Role of Sortase A inFrontiers in microbiology · 2019Article
- Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides.Microbial biotechnology · 2017Article
- The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens.Scientific reports · 2016Article
- High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300.Scientific reports · 2016Article
- Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation.PloS one · 2016Article
- Characterisation of probiotic properties in human vaginal lactobacilli strains.Microbial ecology in health and disease · 2016Article
- Fermented Aloreña Table Olives as a Source of Potential ProbioticFrontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactobacilli are important for the maintenance of a healthy ecosystem in the human vagina. Various mechanisms are postulated but so far are poorly substantiated by molecular studies, such as mutant analysis. Bacterial autoaggregation is an interesting phenomenon that can promote adhesion to host cells and displacement of pathogens. In this study, we report on the identification of a human vaginal isolate, Lactobacillus plantarum strain CMPG5300, which shows high autoaggregative and adhesive capacity. To investigate the importance of sortase-dependent proteins (SDPs) in these phenotypes, a gene deletion mutant was constructed for srtA, the gene encoding the housekeeping sortase that covalently anchors these SDPs to the cell surface. This mutant lost the capacity to autoaggregate, showed a decrease in adhesion to vaginal epithelial cells, and lost biofilm-forming capacity under the conditions tested. These results indicate that the housekeeping sortase SrtA of CMPG5300 is a key determinant of the peculiar surface properties of this vaginal Lactobacillus strain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.