ArticleYonsei medical journal2013
The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma.
Article in Yonsei medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Depicting growth characteristics with computed tomography for KRAS-mutated lung adenocarcinoma.Quantitative imaging in medicine and surgery · 2025Article
- Correlation analysis of clinical, pathological, imaging and genetic features of ground-glass nodule featured lung adenocarcinomas between high-risk and non-high-risk individuals.European journal of medical research · 2023Article
- A Hidden Epidemic of "Intermediate Risk" Oropharynx Cancer.Laryngoscope investigative otolaryngology · 2019Review
- Prognostic value ofOncology letters · 2019Article
- Clinicopathologic characteristics and survival outcome in patients with advanced lung adenocarcinoma andJournal of Cancer · 2018Article
- Molecular Testing of Lung Cancers.Journal of pathology and translational medicine · 2017Review
- [Detection and Analysis of EGFR and KRAS Mutation with Lung Adenocarcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Article
- [Detection and Analysis of EGFR and KRAS Mutations in the Patients with Lung Squamous Cell Carcinomas].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Article
- Mutations of EGFR or KRAS and expression of chemotherapy-related genes based on small biopsy samples in stage IIIB and IV inoperable non-small cell lung cancer.Journal of cancer research and clinical oncology · 2014Article
- MEK inhibition in non-small cell lung cancer.Lung cancer (Amsterdam, Netherlands) · 2014Review
- Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay.Chinese journal of cancer · 2014Article
- Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity.BMC cancer · 2014Article
- Molecular Signatures ofClinical pathology (Thousand Oaks, Ventura County, Calif.)Article
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Authors and funding
13 authors.
Funding
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Abstract
purposeThis study was designed to determine the relationship of cigarette smoking to the frequency and qualitative differences among KRAS mutations in lung adenocarcinomas from Korean patients. MATERIALS AND
methodsDetailed smoking histories were obtained from 200 consecutively enrolled patients with lung adenocarcinoma according to a standard protocol. EGFR (exons 18 to 21) and KRAS (codons 12/13) mutations were determined via direct-sequencing.
resultsThe incidence of KRAS mutations was 8% (16 of 200) in patients with lung adenocarcinoma. KRAS mutations were found in 5.8% (7 of 120) of tumors from never-smokers, 15% (6 of 40) from former-smokers, and 7.5% (3 of 40) from current-smokers. The frequency of KRAS mutations did not differ significantly according to smoking history (p=0.435). Never-smokers were significantly more likely than former or current smokers to have a transition mutation (G→A or C→T) rather than a transversion mutation (G→T or G→C) that is known to be smoking-related (p=0.011). In a Cox regression model, the adjusted hazard ratios for the risk of progression with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) were 0.24 (95% CI, 0.14-0.42; p<0.001) for the EGFR mutation and 1.27 (95% CI, 0.58-2.79; p=0.537) for the KRAS mutation.
conclusionCigarette smoking did not influence the frequency of KRAS mutations in lung adenocarcinomas in Korean patients, but influenced qualitative differences in the KRAS mutations.
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