ArticleNature2013
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.
Article in Nature, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 161 citations in OpenAlex.
- Article
- NUP214 in Acute Myeloid Leukemia.Cells · 2025Review
- Personalized Driver Gene Prediction Using Graph Convolutional Networks with Conditional Random Fields.Biology · 2024Article
- CircRHOT1 restricts gastric cancer cell ferroptosis by epigenetically regulating GPX4.Journal of gastrointestinal oncology · 2023Article
- Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair.Cancer management and research · 2022Review
- The multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity.Nucleic acids research · 2021Review
- Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery.Cell cycle (Georgetown, Tex.) · 2020Review
- LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.Oncogene · 2020Article
- Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence.Biogerontology · 2019Article
- Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in GScientific reports · 2019Article
- Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.Free radical biology & medicine · 2019Article
- Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.Nucleic acids research · 2019Article
- 53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage.Nature cell biology · 2019Article
- UFL1 promotes histone H4 ufmylation and ATM activation.Nature communications · 2019Article
- Quantifying Tip60 (Kat5) stratifies breast cancer.Scientific reports · 2019Article
- SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.Science advances · 2019Article
- The CHD6 chromatin remodeler is an oxidative DNA damage response factor.Nature communications · 2019Article
- The Emerging Role of H3K9me3 as a Potential Therapeutic Target in Acute Myeloid Leukemia.Frontiers in oncology · 2019Review
- Tip60 complex promotes expression of a differentiation factor to regulate germline differentiation in female Drosophila.Molecular biology of the cell · 2018Article
- Virus DNA Replication and the Host DNA Damage Response.Annual review of virology · 2018Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2019-04-11Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Abderrahmane Kaidi has institutional finding of misconduct;
- Commented on by
- Commented on by
- Retracted
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The detection of DNA lesions within chromatin represents a critical step in cellular responses to DNA damage. However, the regulatory mechanisms that couple chromatin sensing to DNA-damage signalling in mammalian cells are not well understood. Here we show that tyrosine phosphorylation of the protein acetyltransferase KAT5 (also known as TIP60) increases after DNA damage in a manner that promotes KAT5 binding to the histone mark H3K9me3. This triggers KAT5-mediated acetylation of the ATM kinase, promoting DNA-damage-checkpoint activation and cell survival. We also establish that chromatin alterations can themselves enhance KAT5 tyrosine phosphorylation and ATM-dependent signalling, and identify the proto-oncogene c-Abl as a mediator of this modification. These findings define KAT5 tyrosine phosphorylation as a key event in the sensing of genomic and chromatin perturbations, and highlight a key role for c-Abl in such processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.