ArticlePediatric nephrology (Berlin, Germany)2013
Vitamin D in nephrotic syndrome remission: a case-control study.
Article in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- The effect of vitamin D and calcium supplementation in pediatric steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Trial
- Vitamin D Deficiency in Relapsing Idiopathic Nephrotic Syndrome in Children: Prevalence, Correlates, and Therapeutic Implications.International journal of endocrinology · 2025Article
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- Vitamin D supplementation in children and young adults with persistent proteinuria secondary to glomerular disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification.International journal of molecular sciences · 2020Review
- Treatment of nephrotic syndrome: going beyond immunosuppressive therapy.Pediatric nephrology (Berlin, Germany) · 2020Review
- Free vitamin D levels in steroid-sensitive nephrotic syndrome and healthy controls.Pediatric nephrology (Berlin, Germany) · 2020Observational
- Bone Health in Glomerular Kidney Disease.Current osteoporosis reports · 2019Review
- Difficult-to-treat idiopathic nephrotic syndrome: established drugs, open questions and future options.Pediatric nephrology (Berlin, Germany) · 2018Review
- Treatment of Genetic Forms of Nephrotic Syndrome.Frontiers in pediatrics · 2018Review
- Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases.Current medicinal chemistry · 2018Review
- Role of Vitamin D in Uremic Vascular Calcification.BioMed research international · 2017Review
- Vitamin D in incident nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study.Pediatric nephrology (Berlin, Germany) · 2016Observational
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundVitamin D deficiency may contribute to osteoporosis in nephrotic syndrome (NS).
methodsA cross-sectional case-control study was performed to investigate 25 hydroxycholecalciferol [25(OH)D] status in 40 patients with NS in remission and 40 healthy controls. Serum levels of 25(OH)D, calcium, phosphate, alkaline phosphatase (ALP), and intact parathyroid hormone (PTH) were assayed. NS patients were segregated by age at onset, current age, type and duration of NS, months since relapse and current drug therapy.
resultsLevels of 25(OH)D showed a positive correlation with months elapsed since last NS relapse (r s = +0.4, p = 0.012) and were lower in NS patients within 3 months of relapse but similar to that of controls in patients in remission for >3 months [median 14.23 (interquartile range 12.19-17.63) vs. 19.75 (14.04-28.38) ng/ml, respectively; p = 0.039]. There was no correlation of 25(OH)D levels with other disease characteristics or drug therapy. ALP levels were also lowest after relapse (r s = +0.34, p = 0.036). Overall, 25(OH)D levels of <20 ng/ml occurred in 62.5 % of NS patients + controls, and correlated negatively with age (r s = -0.24, p = 0.037) but showed no significant correlation with calcium, phosphate, or PTH levels.
conclusionsIn our patients with NS, vitamin D stores remained low for 3 months after NS relapse but showed an increase with longer remission time to control levels. Vitamin D stores were not influenced by disease characteristics or therapy. Longitudinal studies are required to confirm these findings and evaluate the effect of vitamin D on bones, particularly in frequent relapsers.
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