SynthesisSurgical endoscopy2013
Chylothorax after esophagectomy for cancer: impact of the surgical approach and neoadjuvant treatment: systematic review and institutional analysis.
Synthesis in Surgical endoscopy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Management of chyle leaks following esophageal resection: a systematic review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Pooled it
- Fluorescence Lymphography Using Indocyanine Green During Esophagectomy for Cancer to Prevent Chyle Leakage: A Propensity Score Matched Analysis.Annals of surgical oncology · 2026Observational
- A case of refractory chylothorax due to an unenclosed esophageal hiatus after subtotal esophagectomy treated with lipiodol lymphangiography.Surgical case reports · 2024Article
- Risk Factors and Treatment of Chylothorax After Minimally Invasive Esophagectomy for Esophageal Cancer.Cureus · 2024Article
- Does Thoracic Duct Ligation at the Time of Esophagectomy Impact Long-Term Survival? An Individual Patient Data Meta-Analysis.Journal of clinical medicine · 2024Review
- Postesophagectomy chylothorax: a review of the risk factors, diagnosis, and management.Annals of medicine and surgery (2012) · 2023Article
- Clinical implications of chyle leakage following esophagectomy.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Article
- Incidence of chylothorax over nineteen years of transhiatal esophagectomy: A case series and review study.Turkish journal of surgery · 2022Article
- Computed tomography-guided lymphangiography from the para-aortic lymph node: a useful approach for chylothorax after esophagectomy.General thoracic and cardiovascular surgery · 2022Article
- Management options for post-esophagectomy chylothorax.Surgery today · 2021Review
- Management of chyle leakage after general thoracic surgery: Impact of thoracic duct embolization.Thoracic cancer · 2021Article
- Article
- The influence of thoracic duct ligation on long-term survival of patients with esophageal cancer: a propensity score-matched analysis.Journal of thoracic disease · 2020Article
- Evaluating the Surgeon's Experience as a Risk Factor for Post-Esophagectomy Chylothorax on a Four-Year Cohort.Cureus · 2020Article
- Association between low-fat enteral nutrition after esophagectomy and a lower incidence of chyle leakage: A call for more and better evidence.The Journal of international medical research · 2020Article
- Intranodal lymphangiography for chyle leakage after esophagectomy: A case report.Molecular and clinical oncology · 2020Article
- Posterior retroperitoneoscopic thoracic duct ligation: a novel surgical approach.Surgical endoscopy · 2018Article
- Clinical usefulness of the surgical Apgar score for estimating short-term and prognostic outcomes after esophagectomy.Journal of thoracic disease · 2018Article
- [Treatment of chylothorax].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Article
- Laparoscopic management of refractory chylous ascites using fluorescence navigation with indocyanine green: A case report.International journal of surgery case reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophagectomy is a challenging operation with considerable potential for postoperative complications, including chylothorax.
methodsBecause no randomized controlled trial or metaanalysis is available to clarify the incidence of chylothorax in esophageal cancer surgery, the authors analyzed their own institutional data for 1,856 patients and performed a systematic review using the MEDLINE database (9,794 patients) to identify risk factors, compare success rates of therapeutic approaches, and investigate long-term outcomes.
resultsThe overall institutional chylothorax rate was 2 % (n = 39). Reoperation was performed for 69 % of the patients. No significant difference was noted between the transthoracic and transhiatal approaches. Regression analysis showed neoadjuvant treatment (odds ratio [OR], 0.302; p = 0.001) and tumor type (OR, 0.304; p = 0.002) to be independent risk factors. The systematic review included 12 studies. Chylothorax occurred for 2.6 % of the patients. Treatment favored reoperation in five studies (70-100 %) and a conservative approach in four studies (58-72 %), with equal mortality rates. No significant difference was found between the transthoracic and transhiatal approaches.
conclusionChylothorax rates are low in high-volume centers (2-3 %). No significant difference was noted between the transthoracic and transhiatal approaches. Neoadjuvant treatment and tumor type were shown to be independent risk factors. Treatment concept (reoperation vs conservative treatment) did not affect long-term survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.