ReviewCellular and molecular life sciences : CMLS2014
Deconvoluting the ontogeny of hematopoietic stem cells.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study.The Lancet. Haematology · 2018Trial
- The Immunopathogenesis of uveitis.Frontiers in medicine · 2026Review
- Cardiomyocyte proliferation: Advances and insights in macrophage-targeted therapy for myocardial injury.Genes & diseases · 2025Review
- Macrophages and Pulmonary Fibrosis.Current molecular medicine · 2025Review
- New Insights in Immunometabolism in Neonatal Monocytes and Macrophages in Health and Disease.International journal of molecular sciences · 2023Review
- Macrophage Fate Mapping.Current protocols · 2022Article
- Resident macrophages of the lung and liver: The guardians of our tissues.Frontiers in immunology · 2022Review
- Resident Innate Immune Cells in the Cornea.Frontiers in immunology · 2021Review
- γδTCR-independent origin of neonatal γδ T cells prewired for IL-17 production.Current opinion in immunology · 2019Review
- Pathogenic stromal cells as therapeutic targets in joint inflammation.Nature reviews. Rheumatology · 2018Review
- Unified nexus of macrophages and maresins in cardiac reparative mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Review
- Skeletal muscle inflammation and atrophy in heart failure.Heart failure reviews · 2017Review
- Intraperitoneal Injection of Multiplacentas Pooled Cells Treatment on a Mouse Model with Aplastic Anemia.Stem cells international · 2016Article
- Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Origin and functions of tissue macrophages.Immunity · 2014Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two different models describe the development of definitive hematopoiesis and hematopoietic stem cells (HSCs). In one of these, the visceral yolk sac serves as a starting point of relatively lengthy developmental process culminating in the fetal liver hematopoiesis. In another, the origin of adult hematopoiesis is split between the yolk sac and the dorsal aorta, which has a peculiar capacity to generate definitive HSCs. Despite a large amount of experimental data consistent with the latter view, it becomes increasingly unsustainable in the light of recent cell tracing studies. Moreover, analysis of the published studies supporting the aorta-centered version uncovers significant caveats in standard experimental approach and argumentation. As a result, the theory cannot offer feasible cellular mechanisms of the HSC emergence. This review summarizes key efforts to discern the developmental pathway of the adult-type HSCs and attempts to put forward a hypothesis on the inflammatory mechanisms of hematopoietic ontogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.