ReviewArchivum immunologiae et therapiae experimentalis2013
Memory CD4 T cell-mediated immunity against influenza A virus: more than a little helpful.
Review in Archivum immunologiae et therapiae experimentalis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Trial
- H5N1 Avian Influenza: A Narrative Review of Scientific Advances and Global Policy Challenges.Viruses · 2025Review
- Senescent T cells: Beneficial and detrimental roles.Immunological reviews · 2023Review
- STAT1 Controls the Functionality of Influenza-Primed CD4 T Cells but Therapeutic STAT4 Engagement Maximizes Their Antiviral Impact.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Protective Efficacy of a Mucosal Influenza Vaccine Formulation Based on the Recombinant Nucleoprotein Co-Administered with a TLR2/6 Agonist BPPcysMPEG.Pharmaceutics · 2023Article
- Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates.Cold Spring Harbor perspectives in biology · 2021Review
- Memory CD4Cells · 2020Review
- Progress on chicken T cell immunity to viruses.Cellular and molecular life sciences : CMLS · 2019Review
- Mouse Models Reveal Role of T-Cytotoxic and T-Reg Cells in Immune Response to Influenza: Implications for Vaccine Design.Viruses · 2019Review
- Broad CD8Nature communications · 2018Article
- Early programming and late-acting checkpoints governing the development of CD4 T-cell memory.Immunology · 2018Review
- The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?Human vaccines & immunotherapeutics · 2018Review
- Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host.Current opinion in virology · 2018Review
- A Comprehensive Review on Equine Influenza Virus: Etiology, Epidemiology, Pathobiology, Advances in Developing Diagnostics, Vaccines, and Control Strategies.Frontiers in microbiology · 2018Review
- M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection.Mucosal immunology · 2018Article
- Article
- Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection.PloS one · 2017Article
- Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?Frontiers in immunology · 2017Review
- Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The Differentiation and Protective Function of Cytolytic CD4 T Cells in Influenza Infection.Frontiers in immunology · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Recent observations have uncovered multiple pathways whereby CD4 T cells can contribute to protective immune responses against microbial threats. Incorporating the generation of memory CD4 T cells into vaccine strategies thus presents an attractive approach toward improving immunity against several important human pathogens, especially those against which antibody responses alone are inadequate to confer long-term immunity. Here, we review how memory CD4 T cells provide protection against influenza viruses. We discuss the complexities of protective memory CD4 T cell responses observed in animal models and the potential challenges of translating these observations into the clinic. Specifically, we concentrate on how better understanding of organ-specific heterogeneity of responding cells and defining multiple correlates of protection might improve vaccine-generated memory CD4 T cells to better protect against seasonal, and more importantly, pandemic influenza.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.