ArticleNature nanotechnology2013
Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell.
Article in Nature nanotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed.
- Programming DNA machines to move.Nature reviews. Chemistry · 2026Review
- Minor groove tetrads: a potent and versatile capping interaction for i-motif structures.Biophysical reviews · 2026Review
- Organelles harbour pH gradients.Research square · 2026Article
- Organelles harbour pH gradients.bioRxiv : the preprint server for biology · 2025Article
- Rational design of tunable pH switches through shadow-strand hybridization-actuated displacement engineering.Nucleic acids research · 2025Article
- Advances in programmable DNA nanostructures enabling stimuli-responsive drug delivery and multimodal biosensing.RSC chemical biology · 2025Review
- Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells.ACS nano · 2025Review
- DNA nanorobot for mitochondria-targeted microRNAs detection and tailored regulation.Theranostics · 2025Article
- Quantitative Chemical Imaging of Organelles.Accounts of chemical research · 2024Article
- Detecting organelle-specific activity of potassium channels with a DNA nanodevice.Nature biotechnology · 2024Article
- Review
- Zero-Background Small-Molecule Sensors for Near-IR Fluorescent Imaging of Biomacromolecular Targets in Cells.ACS sensors · 2023Article
- DNA-Based Molecular Machines.JACS Au · 2022Review
- Programmable self-regulated molecular buffers for precise sustained drug delivery.Nature communications · 2022Article
- Biosensor-Integrated Drug Delivery Systems as New Materials for Biomedical Applications.Biomolecules · 2022Review
- Review
- Fӧrster resonance energy transfer analysis of amyloid state of proteins.BBA advances · 2022Article
- Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Time-programmable pH: decarboxylation of nitroacetic acid allows the time-controlled rising of pH to a definite value.Chemical science · 2021Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
DNA is a versatile scaffold for molecular sensing in living cells, and various cellular applications of DNA nanodevices have been demonstrated. However, the simultaneous use of different DNA nanodevices within the same living cell remains a challenge. Here, we show that two distinct DNA nanomachines can be used simultaneously to map pH gradients along two different but intersecting cellular entry pathways. The two nanomachines, which are molecularly programmed to enter cells via different pathways, can map pH changes within well-defined subcellular environments along both pathways inside the same cell. We applied these nanomachines to probe the pH of early endosomes and the trans-Golgi network, in real time. When delivered either sequentially or simultaneously, both nanomachines localized into and independently captured the pH of the organelles for which they were designed. The successful functioning of DNA nanodevices within living systems has important implications for sensing and therapies in a diverse range of contexts.
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Registered trials
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