ArticleBiophysical journal2013
The shaft of the type 1 fimbriae regulates an external force to match the FimH catch bond.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- A posttranslational modification of fimbriae drives pathogenicity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A novel post-translational modification of fimbriae drives pathogenicity inbioRxiv : the preprint server for biology · 2025Article
- 3D-printed temperature and shear stress-controlled rocker platform for enhanced biofilm incubation.Scientific reports · 2025Article
- The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili.Nature communications · 2024Article
- Endospore pili: Flexible, stiff, and sticky nanofibers.Biophysical journal · 2023Article
- Three structural solutions for bacterial adhesion pilus stability and superelasticity.Structure (London, England : 1993) · 2023Article
- Extensible membrane nanotubules mediate attachment of Trypanosoma cruzi epimastigotes under flow.PloS one · 2023Article
- Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular Perspective.Microbiology spectrum · 2019Review
- The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?Microorganisms · 2018Review
- Pili Assembled by the Chaperone/Usher Pathway inEcoSal Plus · 2018Review
- The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod.Structure (London, England : 1993) · 2017Article
- A comprehensive guide to pilus biogenesis in Gram-negative bacteria.Nature reviews. Microbiology · 2017Review
- Antibodies Damage the Resilience of Fimbriae, Causing Them To Be Stiff and Tangled.Journal of bacteriology · 2017Article
- Article
- Catch-bond mechanism of the bacterial adhesin FimH.Nature communications · 2016Article
- Antibody-mediated disruption of the mechanics of CS20 fimbriae of enterotoxigenic Escherichia coli.Scientific reports · 2015Article
- Biomechanical and structural features of CS2 fimbriae of enterotoxigenic Escherichia coli.Biophysical journal · 2015Article
- Rigid multibody simulation of a helix-like structure: the dynamics of bacterial adhesion pili.European biophysics journal : EBJ · 2015Article
- Fatal attraction: how bacterial adhesins affect host signaling and what we can learn from them.International journal of molecular sciences · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 fimbriae mediate adhesion of uropathogenic Escherichia coli to host cells. It has been hypothesized that due to their ability to uncoil under exposure to force, fimbriae can reduce fluid shear stress on the adhesin-receptor interaction by which the bacterium adheres to the surface. In this work, we develop a model that describes how the force on the adhesin-receptor interaction of a type 1 fimbria varies as a bacterium is affected by a time-dependent fluid flow mimicking in vivo conditions. The model combines in vivo hydrodynamic conditions with previously assessed biomechanical properties of the fimbriae. Numerical methods are used to solve for the motion and adhesion force under the presence of time-dependent fluid profiles. It is found that a bacterium tethered with a type 1 pilus will experience significantly reduced shear stress for moderate to high flow velocities and that the maximum stress the adhesin will experience is limited to ∼120 pN, which is sufficient to activate the conformational change of the FimH adhesin into its stronger state but also lower than the force required for breaking it under rapid loading. Our model thus supports the assumption that the type 1 fimbria shaft and the FimH adhesin-receptor interaction are optimized to each other, and that they give piliated bacteria significant advantages in rapidly changing fluidic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.