ArticleJournal of biomedical optics2013
Diffuse optical characterization of an exercising patient group with peripheral artery disease.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Effects of exercise training on calf muscle oxygen extraction and blood flow in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Characterization of a fiber-coupled SPAD camera system for deep-tissue blood-flow measurement using diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- Time-variability of muscle oxygen saturation during graded maximal exercise.European journal of applied physiology · 2026Article
- Comparison of diffuse correlation spectroscopy analytical models for cerebral blood flow measurements.Journal of biomedical optics · 2025Article
- Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy.Neurophotonics · 2025Article
- Incremental shuttle walking test for calf muscle oxygenation assessment in peripheral arterial disease: a cross-sectional study.Scientific reports · 2025Article
- Spatial-Temporal Oxygenation Mapping Using a Near-Infrared Optical Scanner: Towards Peripheral Vascular Imaging.Annals of biomedical engineering · 2023Article
- Measurement of Revascularization Effect Using Near Infrared Spectroscopy in Below the Knee Arteries.Reviews in cardiovascular medicine · 2022Article
- Skeletal Muscle Tissue Saturation Changes Measured Using Near Infrared Spectroscopy During Exercise Are Associated With Post-Occlusive Reactive Hyperaemia.Frontiers in physiology · 2022Article
- Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease.Metabolites · 2021Article
- Quantifying tissue perfusion after peripheral endovascular procedures: Novel tissue perfusion endpoints to improve outcomes.World journal of cardiology · 2021Review
- Evaluation of SLE arthritis using frequency domain optical imaging.Lupus science & medicine · 2021Article
- Utility of a Finger-Mounted Tissue Oximeter with Near-Infrared Spectroscopy to Evaluate Limb Ischemia in Patients with Peripheral Arterial Disease.Annals of vascular diseases · 2019Article
- Portable Near-Infrared Technologies and Devices for Noninvasive Assessment of Tissue Hemodynamics.Journal of healthcare engineering · 2019Review
- Validation of a novel wearable, wireless technology to estimate oxygen levels and lactate threshold power in the exercising muscle.Physiological reports · 2018Article
- Clinical applications of near-infrared diffuse correlation spectroscopy and tomography for tissue blood flow monitoring and imaging.Physiological measurement · 2017Review
- Fast blood flow monitoring in deep tissues with real-time software correlators.Biomedical optics express · 2016Article
- Multiparametric assessment of vascular function in peripheral artery disease: dynamic measurement of skeletal muscle perfusion, blood-oxygen-level dependent signal, and venous oxygen saturation.Circulation. Cardiovascular imaging · 2015Article
- Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise.Journal of biomedical optics · 2015Article
- Modified Beer-Lambert law for blood flow.Biomedical optics express · 2014Article
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Authors and funding
12 authors.
Funding
Abstract
Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (S(t)O(2)) has been demonstrated, this is the first study to assess both S(t)O(2) and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For S(t)O(2), mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean S(t)O(2) is lower in PAD groups by 9.3% to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of S(t)O(2) to baseline is more rapid in controls (p < 0.05). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p < 0.05); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p < 0.05). Additionally, relative rate of return to baseline S(t)O(2) is more rapid among subjects with reduced levels of depression in rBF (p = 0.041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies.
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