ArticleJournal of biomedical optics2013
Polarization control of Raman spectroscopy optimizes the assessment of bone tissue.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Multi-scale cortical bone traits vary in females and males from two mouse models of genetic diversity.JBMR plus · 2024Article
- Triple-gene deletion for osteocalcin significantly impairs the alignment of hydroxyapatite crystals and collagen in mice.Frontiers in physiology · 2023Article
- Bone matrix quality in a developing high-fat diet mouse model is altered by RAGE deletion.Bone · 2022Article
- Compositional assessment of bone by Raman spectroscopy.The Analyst · 2021Review
- Genetic variability affects the skeletal response to immobilization in founder strains of the diversity outbred mouse population.Bone reports · 2021Article
- Raman microspectroscopy demonstrates reduced mineralization of subchondral bone marrow lesions in knee osteoarthritis patients.Bone reports · 2020Article
- Effects of Diabetes on Bone Material Properties.Current osteoporosis reports · 2019Review
- Age-related changes in molecular organization of type I collagen in tendon as probed by polarized SHG and Raman microspectroscopy.Scientific reports · 2019Article
- Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone.Scientific reports · 2019Article
- Raman Spectroscopic and Microscopic Analysis for Monitoring Renal Osteodystrophy Signatures.Biosensors · 2018Article
- Applying Full Spectrum Analysis to a Raman Spectroscopic Assessment of Fracture Toughness of Human Cortical Bone.Applied spectroscopy · 2017Article
- Correlations Between Bone Mechanical Properties and Bone Composition Parameters in Mouse Models of Dominant and Recessive Osteogenesis Imperfecta and the Response to Anti-TGF-β Treatment.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Raman Spectroscopic Analyses of Jaw Periosteal Cell Mineralization.Stem cells international · 2017Article
- Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage.ACS central science · 2016Article
- Changes in the Fracture Resistance of Bone with the Progression of Type 2 Diabetes in the ZDSD Rat.Calcified tissue international · 2016Article
- Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils.Journal of the Royal Society, Interface · 2016Review
- Technologies for assessment of bone reflecting bone strength and bone mineral density in elderly women: an update.Women's health (London, England) · 2016Article
- ZIP4 silencing improves bone loss in pancreatic cancer.Oncotarget · 2015Article
- Anisotropy in bone demineralization revealed by polarized far-IR spectroscopy.Molecules (Basel, Switzerland) · 2015Article
- Contributions of Raman spectroscopy to the understanding of bone strength.BoneKEy reports · 2015Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
There is potential for Raman spectroscopy (RS) to complement tools for bone diagnosis due to its ability to assess compositional and organizational characteristics of both collagen and mineral. To aid this potential, the present study assessed specificity of RS peaks to the composition of bone, a birefringent material, for different degrees of instrument polarization. Specifically, relative changes in peaks were quantified as the incident light rotated relative to the orientation of osteonal and interstitial tissue, acquired from cadaveric femurs. In a highly polarized instrument (10(6)∶1 extinction ratio), the most prominent mineral peak (ν1 Phosphate at 961 cm(-1)) displayed phase similarity with the Proline peak at 856 cm(-1). This sensitivity to relative orientation between bone and light observed in the highly polarized regime persisted for certain sensitive peaks (e.g., Amide I at 1666 cm(-1)) in unaltered instrumentation (200∶1 extinction ratio). Though Proline intensity changed with bone rotation, the phase of Proline matched that of ν1 Phosphate. Moreover, when mapping ν1 Phosphate/Proline across osteonal-interstitial borders, the mineralization difference between the tissue types was evident whether using a 20x or 50x objectives. Thus, the polarization bias inherent in commercial RS systems does not preclude the assessment of bone composition when using phase-matched peaks.
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