ArticleNature neuroscience2013
BMP signaling specifies the development of a large and fast CNS synapse.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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Who cites it
57 citing papers in PubMed.
- Input-Specific Organization of Intrinsic Excitability Expands Coding Capacity of Fast-Spiking Auditory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pre-Sensory Spontaneous Activity Accelerates Coordinated Maturation of Synaptic Partners and Drives Transition to the Mature Physiological Phenotype.bioRxiv : the preprint server for biology · 2025Article
- Therapeutic challenges and new therapeutic targets for combined capillary pulmonary hypertension: a review.Frontiers in medicine · 2025Review
- Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus.Molecular psychiatry · 2024Article
- The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification.Neurochemical research · 2024Review
- Article
- Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections.Frontiers in cellular neuroscience · 2024Article
- Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.Nature communications · 2023Article
- Long-term microglia depletion impairs synapse elimination and auditory brainstem function.Scientific reports · 2022Article
- Synapse Maturation and Developmental Impairment in the Medial Nucleus of the Trapezoid Body.Frontiers in integrative neuroscience · 2022Review
- Volume electron microscopy reveals age-related circuit remodeling in the auditory brainstem.Frontiers in cellular neuroscience · 2022Article
- Loss of miR-183/96 Alters Synaptic Strength via Presynaptic and Postsynaptic Mechanisms at a Central Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.Development (Cambridge, England) · 2021Article
- 0.1 THz exposure affects primary hippocampus neuron gene expression via alternating transcription factor binding.Biomedical optics express · 2021Article
- Two types of somatic spines provide sites for intercellular signaling during calyx of Held growth and maturation.Synapse (New York, N.Y.) · 2021Article
- Auditory brainstem development and plasticity.Current opinion in physiology · 2020Article
- A low affinityeLife · 2020Article
- Structure-function relation of the developing calyx of Held synapse in vivo.The Journal of physiology · 2020Article
- Extracellular heparan sulfate proteoglycans and glycan-binding lectins orchestrateJournal of cell science · 2020Review
- LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large excitatory synapses with multiple active zones ensure reliable and fast information transfer at specific points in neuronal circuits. However, the mechanisms that determine synapse size in CNS circuits are largely unknown. Here we use the calyx of Held synapse, a major relay in the auditory system, to identify and study signaling pathways that specify large nerve terminal size and fast synaptic transmission. Using genome-wide screening, we identified bone morphogenetic proteins (BMPs) as candidate signaling molecules in the area of calyx synapses. Conditional deletion of BMP receptors in the auditory system of mice led to aberrations of synapse morphology and function specifically at the calyx of Held, with impaired nerve terminal growth, loss of monoinnervation and less mature transmitter release properties. Thus, BMP signaling specifies large and fast-transmitting synapses in the auditory system in a process that shares homologies with, but also extends beyond, retrograde BMP signaling at Drosophila neuromuscular synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.