ArticleProceedings of the National Academy of Sciences of the United States of America2013
Molecular genetics and subjective well-being.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multivariate genome-wide analyses of the well-being spectrum.Nature genetics · 2019Pooled it
- An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.Biological psychiatry · 2017Pooled it
- Genetics of wellbeing and its components satisfaction with life, happiness, and quality of life: a review and meta-analysis of heritability studies.Behavior genetics · 2015Pooled it
- A systematic review of the neural correlates of positive emotions.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- Trial
- Worldwide Well-Being: Simulated Twins Reveal Genetic and (Hidden) Environmental Influences.Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
- Les Misérables: An analysis of low SWB across the world.Frontiers in psychology · 2023Article
- An investigation into DNA methylation patterns associated with risk preference in older individuals.Epigenetics · 2022Article
- Expression and Clinical Significance of High-Mobility Group AT-hook 2 (HMGA2) in Osteosarcoma.Orthopaedic surgery · 2022Article
- Expanding the environmental scope: an environment-wide association study for mental well-being.Journal of exposure science & environmental epidemiology · 2022Article
- Genome-wide analyses of psychological resilience in U.S. Army soldiers.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- The Genome-Wide Study of Human Social Behavior and Its Application in Sociology.Frontiers in sociology · 2019Review
- A genetic perspective on the relationship between eudaimonic -and hedonic well-being.Scientific reports · 2018Article
- Sociogenomics in the 21Sociology compass · 2018Article
- Genetics, personality and wellbeing. A twin study of traits, facets and life satisfaction.Scientific reports · 2018Article
- Associations between subjective well-being and subcortical brain volumes.Scientific reports · 2017Article
- Biometric Modeling of Gene-Environment Interplay: The Intersection of Theory and Method and Applications for Social Inequality.Journal of personality · 2017Review
- Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.PLoS genetics · 2017Article
- Opportunities and challenges of big data for the social sciences: The case of genomic data.Social science research · 2016Article
- Genetic mapping of canine fear and aggression.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Subjective well-being (SWB) is a major topic of research across the social sciences. Twin and family studies have found that genetic factors may account for as much as 30-40% of the variance in SWB. Here, we study genetic contributions to SWB in a pooled sample of ≈ 11,500 unrelated, comprehensively-genotyped Swedish and Dutch individuals. We apply a recently developed method to estimate "common narrow heritability": the fraction of variance in SWB that can be explained by the cumulative additive effects of genetic polymorphisms that are common in the population. Our estimates are 5-10% for single-question survey measures of SWB, and 12-18% after correction for measurement error in the SWB measures. Our results suggest guarded optimism about the prospects of using genetic data in SWB research because, although the common narrow heritability is not large, the polymorphisms that contribute to it could feasibly be discovered with a sufficiently large sample of individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.