ArticleInternational journal of molecular sciences2013
Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality.
Article in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- APOA1, DEFB103A_DEFB103B and DSG3 Are Novel Circulating Biomarkers of Psoriasis.International journal of molecular sciences · 2026Article
- EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects.Brain : a journal of neurology · 2026Article
- The endolysosomal pathway and ALS/FTD.Trends in neurosciences · 2023Review
- Proteomic profiling of the brain from theEuropean journal of translational myology · 2023Article
- LRRK2 recruitment, activity, and function in organelles.The FEBS journal · 2022Review
- GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins.Frontiers in cell and developmental biology · 2022Article
- Genomic inbreeding and runs of homozygosity analysis of indigenous cattle populations in southern China.PloS one · 2022Article
- Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation.Cells · 2021Review
- Vps54 regulatesBiology open · 2020Article
- Mid-Gestation lethality ofInternational journal of molecular sciences · 2020Article
- ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.The Journal of cell biology · 2019Article
- A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes.Human molecular genetics · 2019Article
- Vaccinia Virus Uses Retromer-Independent Cellular Retrograde Transport Pathways To Facilitate the Wrapping of Intracellular Mature Virions during Virus Morphogenesis.Journal of virology · 2016Article
- Endocytic membrane trafficking and neurodegenerative disease.Cellular and molecular life sciences : CMLS · 2016Review
- Inflammation and neuronal death in the motor cortex of the wobbler mouse, an ALS animal model.Journal of neuroinflammation · 2015Article
- Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.Molecular biology of the cell · 2015Article
- VPS54 and the wobbler mouse.Frontiers in neuroscience · 2015Review
- TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.Molecular and cellular biology · 2014Article
- Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.Bioscience reports · 2014Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of the mutation causing the phenotype of the amyotrophic lateral sclerosis (ALS) model mouse, wobbler, has linked motor neuron degeneration with retrograde vesicle traffic. The wobbler mutation affects protein stability of Vps54, a ubiquitously expressed vesicle-tethering factor and leads to partial loss of Vps54 function. Moreover, the Vps54 null mutation causes embryonic lethality, which is associated with extensive membrane blebbing in the neural tube and is most likely a consequence of impaired vesicle transport. Investigation of cells derived from wobbler and Vps54 null mutant embryos demonstrates impaired retrograde transport of the Cholera-toxin B subunit to the trans-Golgi network and mis-sorting of mannose-6-phosphate receptors and cargo proteins dependent on retrograde vesicle transport. Endocytosis assays demonstrate no difference between wobbler and wild type cells, indicating that the retrograde vesicle traffic to the trans-Golgi network, but not endocytosis, is affected in Vps54 mutant cells. The results obtained on wobbler cells were extended to test the use of cultured skin fibroblasts from human ALS patients to investigate the retrograde vesicle traffic. Analysis of skin fibroblasts of ALS patients will support the investigation of the critical role of the retrograde vesicle transport in ALS pathogenesis and might yield a diagnostic prospect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.