Evidence map›Paper›PMID 23707478›Full record

ReviewTrends in cell biology2013

TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins.

Erin L Doyle, Barry L Stoddard, Daniel F Voytas, Adam J Bogdanove

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Diversity and structural-functional insights of alpha-solenoid proteins.Protein science : a publication of the Protein Society · 2024
    Review
  5. Article
  6. Article
  7. Genome Editing and Protein Energy Malnutrition.Advances in experimental medicine and biology · 2023
    Article
  8. Review
  9. Biotechnological Advances to Improve Abiotic Stress Tolerance in Crops.International journal of molecular sciences · 2022
    Review
  10. Review
  11. Review
  12. Evasion of plant immunity by microbial pathogens.Nature reviews. Microbiology · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Points of View on the Tools for Genome/Gene Editing.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erin L DoyleDepartment of Plant Pathology and Microbiology, Iowa State University, 351 Bessey Hall, Ames, IA 50011, USA.
Barry L Stoddard
Daniel F Voytas
Adam J Bogdanove

Funding

DNA targeting by TAL effectorsR01GM098861 · NIGMS · IOWA STATE UNIVERSITY · PI BOGDANOVE, ADAM J, STODDARD, BARRY L. · 2011 to 2014
$2.0M
NIGMS NIH HHS R01 GM098861
6 · The paper itself

Abstract

Transcription activator-like (TAL) effectors are transcription factors injected into plant cells by pathogenic bacteria of the genus Xanthomonas. They function as virulence factors by activating host genes important for disease, or as avirulence factors by turning on genes that provide resistance. DNA-binding specificity is encoded by polymorphic repeats in each protein that correspond one-to-one with different nucleotides. This code has facilitated target identification and opened new avenues for engineering disease resistance. It has also enabled TAL effector customization for targeted gene control, genome editing, and other applications. This article reviews the structural basis for TAL effector-DNA specificity, the impact of the TAL effector-DNA code on plant pathology and engineered resistance, and recent accomplishments and future challenges in TAL effector-based DNA targeting.

Indexed as

Protein EngineeringDNAPlantsTrans-ActivatorsVirulence FactorsXanthomonasDNATrans-ActivatorsVirulence Factorscrystal structureDNA targetinggene therapyplant diseaseresistance genessusceptibility genesTAL effector nucleases

Identifiers

PMID23707478
PMCPMC3729746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.