ReviewLancet (London, England)2013
Alternatives to blood transfusion.
Review in Lancet (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03952546 (A Prospective, Randomized, Single-blinded, Non-inferiority Study to Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer Compared to the Unipolar Electrocautery in Primary Unilateral Total Knee Arthroplasty), which is not on this map. Cited by 86 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized, Single-blinded, Non-inferiority Study to Evaluate the Safety and Efficacy of the Saline-coupled Bipolar Sealer Compared to the Unipolar Electrocautery in Primary Unilateral Total Knee Arthroplasty
Who cites it
86 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Guideline
- Preoperative hemoglobin and perioperative blood transfusion in major head and neck surgery: a systematic review and meta-analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Pooled it
- Is deliberate hypotension a safe technique for orthopedic surgery?: a systematic review and meta-analysis of parallel randomized controlled trials.Journal of orthopaedic surgery and research · 2019Pooled it
- Recommendations on RBC Transfusion in Infants and Children With Acquired and Congenital Heart Disease From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Guideline
- Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2018Pooled it
- Washed cell salvage in surgical patients: A review and meta-analysis of prospective randomized trials under PRISMA.Medicine · 2016Pooled it
- Cost-effectiveness of cell salvage and donor blood transfusion during caesarean section: results from a randomised controlled trial.BMJ open · 2019Trial
- The effectiveness of a de-implementation strategy to reduce low-value blood management techniques in primary hip and knee arthroplasty: a pragmatic cluster-randomized controlled trial.Implementation science : IS · 2017Trial
- Preoperative Platelet and International Normalized Ratio Thresholds and Their Impact on Complications Following Revision Total Joint Arthroplasty.Arthroplasty today · 2026Article
- First-time red blood cell transfusions in the emergency department: A deficiency in micronutrient testing.Transfusion medicine (Oxford, England) · 2026Article
- AI and Blood Banking: Predicting Transfusion Demand - A Systematic Review of Forecasting Approaches.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026Review
- Perioperative blood management in Jehovah's Witnesses.Die Anaesthesiologie · 2026Review
- Perioperative Patient Blood Management: Evidence-Based Strategies for Surgeons and Anesthesiologists: A Narrative Review.Journal of clinical medicine · 2026Review
- Advancing pharmacist involvement in surgical prehabilitation: a call to action for global pharmacy practice.International journal of clinical pharmacy · 2026Article
- Mismatch between global patient blood management policy and nursing education: evidence from four countries.Frontiers in public health · 2026Article
- [Perioperative blood management in Jehova's Witnesses].Die Anaesthesiologie · 2026Review
- Article
- Perioperative Patient Blood Management in Primary Knee and Hip Arthroplasty-Nonsense or Necessity?Journal of clinical medicine · 2025Article
- Bypass surgery in a Jehovah's Witness with critical limb ischemia and end stage renal disease: a case report.Journal of surgical case reports · 2025Article
- A Retrospective Single-Center Cohort Study on Heme Transfusions in Orthopedic Surgeries.Cureus · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of alternatives to allogeneic blood continues to rest on the principles that blood transfusions have inherent risks, associated costs, and affect the blood inventory available for health-care delivery. Increasing evidence exists of a fall in the use of blood because of associated costs and adverse outcomes, and suggests that the challenge for the use of alternatives to blood components will similarly be driven by costs and patient outcomes. Additionally, the risk-benefit profiles of alternatives to blood transfusion such as autologous blood procurement, erythropoiesis-stimulating agents, and haemostatic agents are under investigation. Nevertheless, the inherent risks of blood, along with the continued rise in blood costs are likely to favour the continued development and use of alternatives to blood transfusion. We summarise the current roles of alternatives to blood in the management of medical and surgical anaemias.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.