Evidence map›Paper›PMID 23706517›Full record

SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2014

Personality and risk of Alzheimer's disease: new data and meta-analysis.

Antonio Terracciano, Angelina R Sutin, Yang An, Richard J O'Brien, Luigi Ferrucci, Alan B Zonderman, Susan M Resnick

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 8 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 8 syntheses or guidelines pooled it, 331 citations in OpenAlex.

  1. Pooled it
  2. The Association Between Five Factor Model Personality Traits and Verbal and Numeric Reasoning.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022
    Pooled it
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  5. Personality and Cognitive Decline in Older Adults: Data From a Longitudinal Sample and Meta-Analysis.The journals of gerontology. Series B, Psychological sciences and social sciences · 2016
    Pooled it
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  9. Trial
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  12. Review
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  17. Observational
  18. Review
  19. High-frequency assessment of mood, personality, and cognition in healthy younger, healthy older and adults with cognitive impairment.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024
    Article
  20. Psychosocial experiences are associated with human brain mitochondrial biology.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Antonio TerraccianoNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Florida State University College of Medicine, Tallahassee, FL, USA. Electronic address: antonio.terracciano@med.fsu.edu.
Angelina R SutinNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Florida State University College of Medicine, Tallahassee, FL, USA.
Yang AnNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Richard J O'BrienDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Alan B ZondermanNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Susan M ResnickNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Florida State University · USNational Institute on Aging · USNational Institutes of Health · USJohns Hopkins University · US

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
Early Markers of Alzheimer DiseaseZIAAG000185 · NIA · NATIONAL INSTITUTE ON AGING · PI WALKER, KEENAN · 2009 to 2025
$20.4M
Basic Research In Personality: AgingZIAAG000183 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2009 to 2020
$2.8M
Psychosocial Predictors of Mental and Physical Health: PsychopathologyZIAAG000197 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2009 to 2010
$334k
Intramural NIH HHS Z99 AG999999Intramural NIH HHS ZIA AG000183Intramural NIH HHS ZIA AG000197NIA NIH HHS P50 AG005146
6 · The paper itself

Abstract

backgroundWe examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies.

methodsParticipants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054).

resultsIndividuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6-6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval = 1.4-7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism (P = 2 × 10(-9)) and conscientiousness (P = 2 × 10(-6)), along with weaker effects for openness and agreeableness (P < .05).

conclusionsThe current study and meta-analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well-established clinical and lifestyle risk factors.

Indexed as

Alzheimer DiseasePersonalityAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsPersonality InventoryAlzheimer's diseaseAnxietyAPOEConscientiousnessDementiaDepressionMeta-analysisNeuroticismObservational prospective studyOrderSelf-discipline

Identifiers

PMID23706517
PMCPMC3783589
OpenAlexW2029438618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.