ArticleThe Journal of pediatrics2013
Low incidence of pathology detection and high cost of screening in the evaluation of asymptomatic short children.
Article in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Clinical and biochemical evaluation of children with short stature in the primary care setting: a systematic review.Italian journal of pediatrics · 2026Pooled it
- Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.Hormone research in paediatrics · 2019Guideline
- Pituitary MRI, Clinical and Biochemical Findings in Children With Growth Disorder: A Retrospective Comparative Study.Cureus · 2026Article
- Unraveling the genetic links between stature and disease in East Asians: A multi-biobank genetic correlation and risk prediction study.PLoS genetics · 2026Article
- Familial short stature: genetic architecture, risk stratification, and precision management.Frontiers in endocrinology · 2026Review
- A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature.Genome medicine · 2025Article
- Contribution of Dynamic and Genetic Tests for Short Stature Diagnosing: A Case Report.Diagnostics (Basel, Switzerland) · 2023Article
- Evaluating the sensitivity and specificity of the UK and Dutch growth referral criteria in predicting the diagnosis of pathological short stature.BMJ paediatrics open · 2022Observational
- Novel Insights Into the Genetic Causes of Short Stature in Children.TouchREVIEWS in endocrinology · 2022Review
- Delphi consensus on the diagnosis and treatment of patients with short stature in Spain: GROW-SENS study.Journal of endocrinological investigation · 2022Article
- Balanced assessment of growth disorders using clinical, endocrinological, and genetic approaches.Annals of pediatric endocrinology & metabolism · 2021Article
- Whole-Exome Sequencing in Idiopathic Short Stature: Rare Mutations Affecting Growth.Journal of pediatric genetics · 2021Article
- Identification and characterization of factors associated with short stature and pre-shortness in Chinese preschool-aged children.Endocrine connections · 2021Article
- Definition and prevalence of familial short stature.Italian journal of pediatrics · 2021Article
- Growth failure: 'idiopathic' only after a detailed diagnostic evaluation.Endocrine connections · 2021Review
- Sitting Height to Standing Height Ratio Reference Charts for Children in the United States.The Journal of pediatrics · 2020Article
- A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth FailureJournal of clinical research in pediatric endocrinology · 2020Review
- Short stature andPeerJ · 2020Article
- Achieving Optimal Short- and Long-term Responses to Paediatric Growth Hormone TherapyJournal of clinical research in pediatric endocrinology · 2019Review
- Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning.Journal of biomedical science · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the incidence of pathology during routine screening of healthy short children, testing adherence to a consensus statement on the diagnosis and treatment of children with idiopathic short stature, and the cost per identified diagnosis resulting from comprehensive screening. STUDY
designRetrospective chart review of 1373 consecutive short stature referrals evaluated at the Cincinnati Children's Hospital Medical Center Pediatric Endocrinology Clinic between 2008 and 2011. We identified 235 patients with a height of <3rd percentile, negative history and review of systems, and normal physical examination. Outcome measures were incidence of pathology detection, diagnostic group characteristics, clinicians' adherence to testing guidelines, and screening costs. ANOVA and χ(2) were used to analyze the data.
resultsNearly 99% of patients were diagnosed as possible variants of normal growth: 23% with familial short stature, 41% with constitutional delay of growth and maturation, and 36% with idiopathic short stature. The incidence of newly diagnosed pathology was 1.3%: 1 patient with biopsy-proved celiac disease, 1 with unconfirmed celiac disease, and 1 with potential insulin-like growth factor I receptor defect. On average, each patient had 64.3% of the recommended tests for age and sex; 2.1% of patients had all of the recommended testing. The total screening tests costs were $315321, yielding $105107 per new diagnosis entertained.
conclusionsHealthy short children do not warrant nondirected, comprehensive screening. Future guidelines for evaluating short stature should include patient-specific testing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.