SynthesisFertility and sterility2013
Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis.
Synthesis in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07225660 (A Randomized Blinded Controlled Trial Assessing Hormonal Optimization), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Blinded Controlled Trial Assessing Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Update on fertility preservation from the Barcelona International Society for Fertility Preservation-ESHRE-ASRM 2015 expert meeting: indications, results and future perspectives.Human reproduction (Oxford, England) · 2017Guideline
- Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance.Human reproduction update · 2017Pooled it
- The development and phase 1 evaluation of a Decision Aid for elective egg freezing.BMC medical informatics and decision making · 2023Trial
- Effect of different rehydration temperatures on the survival of human vitrified-warmed oocytes.Journal of assisted reproduction and genetics · 2015Trial
- Fertility Attitudes of Adolescents and Young Adults With Turner Syndrome and Their Parents/Guardians: A Pilot Cross-Sectional Survey Study.Journal of pediatric and adolescent gynecology · 2026Article
- Impact of embryo storage time after vitrification on pregnancy and implantation rates.JBRA assisted reproduction · 2025Article
- Federated task-adaptive learning for personalized selection of human IVF-derived embryos.Communications medicine · 2025Article
- Nesting the Eggs on Another Day: Social Egg Freezing.Journal of obstetrics and gynaecology of India · 2025Review
- Trends and Regional Differences for Fertility Preservation Procedures in Women With Breast Cancer.Clinical breast cancer · 2025Article
- Global Mapping and Visualization Analysis of Almost Five Decades of Egg Freezing Research: Trends, Hotspots and Prospects.International journal of women's health · 2025Article
- Blastocyst formation in vitrified-warmed preimplantation embryos derived from vitrified-warmed oocytes in a mouse model.Clinical and experimental reproductive medicine · 2024Article
- Exploring the knowledge, attitudes, and perceptions of women of reproductive age towards fertility and elective oocyte cryopreservation for age-related fertility decline in the UK: a cross-sectional survey.Human reproduction (Oxford, England) · 2023Article
- Fertility Preservation as an Option for Women with Genetic Disorders: Insights from a SWOT Analysis on Elective Oocyte Freezing and Preimplantation Genetic Testing.Life (Basel, Switzerland) · 2023Article
- Social egg freezing: Motivations, treatment experiences and the impact of Covid-19 - a single-center experience.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?Human reproduction (Oxford, England) · 2022Review
- Comparing the effects of a commercial and a prototype vitrification medium on meiotic spindle morphology and survival rate of mouse oocytes.JBRA assisted reproduction · 2022Article
- Article
- Decision regret and associated factors following oocyte cryopreservation in patients with diminished ovarian reserve and/or age-related fertility decline.Journal of assisted reproduction and genetics · 2021Article
- Elective oocyte cryopreservation for age-related fertility decline.Journal of assisted reproduction and genetics · 2021Article
- Systematic review of fertility preservation options in transgender patients: a guide for plastic surgeons.Annals of translational medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles.
designIndividual patient data meta-analysis.
settingAssisted reproduction centers. PATIENT(S): Infertile patients undergoing ND mature oocyte cryopreservation. INTERVENTION(S): PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen-thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data. MAIN OUTCOME MEASURE(S): Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. RESULT(S): Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen. CONCLUSION(S): The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.