ArticleMaterials science & engineering. C, Materials for biological applications2013
Osteogenic and antimicrobial nanoparticulate calcium phosphate and poly-(D,L-lactide-co-glycolide) powders for the treatment of osteomyelitis.
Article in Materials science & engineering. C, Materials for biological applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- PLGA-Based Co-Delivery Nanoformulations: Overview, Strategies, and Recent Advances.Pharmaceutics · 2025Review
- Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials.International journal of molecular sciences · 2024Review
- Calcium Phosphate Delivery Systems for Regeneration and Biomineralization of Mineralized Tissues of the Craniofacial Complex.Molecular pharmaceutics · 2023Review
- When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-Journal of functional biomaterials · 2022Article
- Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics.Nanomaterials (Basel, Switzerland) · 2020Review
- [Bone substitute materials as local drug carriers : Current status of substitutes of various origins].Der Orthopade · 2018Review
- Nanomedicine for safe healing of bone trauma: Opportunities and challenges.Biomaterials · 2017Review
- Population Effects of Calcium Phosphate Nanoparticles inACS biomaterials science & engineering · 2017Article
- Bone biomaterials and interactions with stem cells.Bone research · 2017Review
- Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro?Biochimica et biophysica acta · 2016Article
- Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.Biomaterials · 2016Review
- Chitosan-PLGA polymer blends as coatings for hydroxyapatite nanoparticles and their effect on antimicrobial properties, osteoconductivity and regeneration of osseous tissues.Materials science & engineering. C, Materials for biological applications · 2016Article
- Organic Nanomaterials and Their Applications in the Treatment of Oral Diseases.Molecules (Basel, Switzerland) · 2016Review
- When 1+1>2: Nanostructured composites for hard tissue engineering applications.Materials science & engineering. C, Materials for biological applications · 2015Review
- Effects of fluoridation of porcine hydroxyapatite on osteoblastic activity of human MG63 cells.Science and technology of advanced materials · 2015Article
- Design and development of intraocular polymeric implant systems for long-term controlled-release of clindamycin phosphate for toxoplasmic retinochoroiditis.Advanced biomedical research · 2015Article
- Nanostructured platforms for the sustained and local delivery of antibiotics in the treatment of osteomyelitis.Critical reviews in therapeutic drug carrier systems · 2015Review
- Nanoparticulate drug delivery platforms for advancing bone infection therapies.Expert opinion on drug delivery · 2014Review
- Simultaneous bactericidal and osteogenic effect of nanoparticulate calcium phosphate powders loaded with clindamycin on osteoblasts infected with Staphylococcus aureus.Materials science & engineering. C, Materials for biological applications · 2014Article
- In vitro analysis of nanoparticulate hydroxyapatite/chitosan composites as potential drug delivery platforms for the sustained release of antibiotics in the treatment of osteomyelitis.Journal of pharmaceutical sciences · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Development of a material for simultaneous sustained and localized delivery of antibiotics and induction of spontaneous regeneration of hard tissues affected by osteomyelitis stands for an important clinical need. In this work, a comparative analysis of the bacterial and osteoblastic cell response to two different nanoparticulate carriers of clindamycin, an antibiotic commonly prescribed in the treatment of bone infection, one composed of calcium phosphate and the other comprising poly-(D,L-lactide-co-glycolide)-coated calcium phosphate, was carried out. Three different non-cytotoxic phases of calcium phosphate, exhibiting dissolution and drug release profiles in the range of one week to two months to one year, respectively, were included in the analysis: monetite, amorphous calcium phosphate and hydroxyapatite. Spherical morphologies and narrow size distribution of both types of nanopowders were confirmed in transmission and scanning electron microscopic analyses. The antibiotic-containing powders exhibited sustained drug release contingent upon the degradation rate of the carrier. Assessment of the antibacterial performance of the antibiotic-encapsulated powders against Staphylococcus aureus, the most common pathogen isolated from infected bone, yielded satisfactory results both in broths and on blood agar plates for all the analyzed powders. In contrast, no cytotoxic behavior was detected upon the incubation of the antibiotic powders with the osteoblastic MC3T3-E1 cell line for up to three weeks. The cells were shown to engage in a close contact with the antibiotic-containing particles, irrespective of their internal or surface phase composition, polymeric or mineral. At the same time, both types of particles upregulated the expression of osteogenic markers osteocalcin, osteopontin, Runx2 and protocollagen type I, suggesting their ability to promote osteogenesis and enhance remineralization of the infected site in addition to eliminating the bacterial source of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.