Evidence map›Paper›PMID 23706025›Full record

Trial reportBMC neurology2013

Robot-assisted walking training for individuals with Parkinson's disease: a pilot randomized controlled trial.

Patrizio Sale, Maria Francesca De Pandis, Domenica Le Pera, Ivan Sova, Veronica Cimolin, Andrea Ancillao, Giorgio Albertini, Manuela Galli, Fabrizio Stocchi, Marco Franceschini

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01668407 nacompletednot on this map

Use of a Robot for the Rehabilitation of Walking in Patients With Parkinson's Disease.

TypeinterventionalSponsorIRCCS San Raffaele RomaRan2012 to 2016Enrolled80ConditionsIdiopathic Parkinson's Disease, Progressive Supranuclear PalsyArmsRobot-Assisted Gait Training (RAGT), Treadmill Gait Training (TT)
NCT04778852 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Quantitative Assessment of Training Effects Using a Wearable Exoskeleton in Parkinson Disease Patients

TypeinterventionalSponsorUniversity of PadovaRan2020 to 2023Enrolled50ConditionsParkinson DiseaseArmsExperimental: EksoGT, Functional kinematic training
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  6. Treadmill training for patients with Parkinson's disease.The Cochrane database of systematic reviews · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Patrizio Sale
Maria Francesca De Pandis
Domenica Le Pera
Ivan Sova
Veronica Cimolin
Andrea Ancillao
Giorgio Albertini
Manuela Galli
Fabrizio Stocchi
Marco Franceschini

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the last years, the introduction of robotic technologies into Parkinson's disease rehabilitation settings has progressed from concept to reality. However, the benefit of robotic training remains elusive. This pilot randomized controlled observer trial is aimed at investigating the feasibility, the effectiveness and the efficacy of new end-effector robot training in people with mild Parkinson's disease.

methodsDesign. Pilot randomized controlled trial.

resultsRobot training was feasible, acceptable, safe, and the participants completed 100% of the prescribed training sessions. A statistically significant improvement in gait index was found in favour of the EG (T0 versus T1). In particular, the statistical analysis of primary outcome (gait speed) using the Friedman test showed statistically significant improvements for the EG (p = 0,0195). The statistical analysis performed by Friedman test of Step length left (p = 0,0195) and right (p = 0,0195) and Stride length left (p = 0,0078) and right (p = 0,0195) showed a significant statistical gain. No statistically significant improvements on the CG were found.

conclusionsRobot training is a feasible and safe form of rehabilitative exercise for cognitively intact people with mild PD. This original approach can contribute to increase a short time lower limb motor recovery in idiopathic PD patients. The focus on the gait recovery is a further characteristic that makes this research relevant to clinical practice. On the whole, the simplicity of treatment, the lack of side effects, and the positive results from patients support the recommendation to extend the use of this treatment. Further investigation regarding the long-time effectiveness of robot training is warranted.

trial registrationClinicalTrials.gov NCT01668407.

Indexed as

AgedAged, 80 and overExercise TherapyFeasibility StudiesFemaleGaitHumansMaleMiddle AgedParkinson DiseasePilot ProjectsRoboticsTreatment OutcomeWalking

Identifiers

PMID23706025
PMCPMC3665527

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.