ArticleDiabetic foot & ankle2013
Pressure pain perception in the diabetic Charcot foot: facts and hypotheses.
Article in Diabetic foot & ankle, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- [Concept of plantarization for toe correction in diabetic foot syndrome].Operative Orthopadie und Traumatologie · 2016Trial
- Corneal confocal microscopy detects severe small fiber neuropathy in diabetic patients with Charcot neuroarthropathy.Journal of diabetes investigation · 2018Article
- Electrophysiological and psychophysical correlates of spatial summation to noxious heat: the possible role of A-delta fibers.Experimental brain research · 2017Article
- Conventional deep pressure algometry is not suitable for clinical assessment of nociception in painless diabetic neuropathy.Diabetic foot & ankle · 2016Article
- Effect of painless diabetic neuropathy on pressure pain hypersensitivity (hyperalgesia) after acute foot trauma.Diabetic foot & ankle · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReduced traumatic and posttraumatic (nociceptive) pain is a key feature of diabetic neuropathy. Underlying condition is a gradual degeneration of endings of pain nerves (A-delta fibers and C-fibers), which operate as receivers of noxious stimuli (nociceptors). Hence, the absence of A-delta fiber mediated sharp pain ("first" pain), and of C-fiber mediated dull pain ("second" pain). However, patients with diabetic neuropathy and acute Charcot foot often experience deep dull aching in the Charcot foot while walking on it.
aimTo create a unifying hypothesis on the kind of pain in an acute Charcot foot.
resultAbsence of punctuate (pinprick) pain perception at the sole of a Charcot foot, as was shown recently, likely corresponds to vanished intraepidermal A-delta fiber endings. C-fiber nociceptors are reduced, according to histopathology studies. Both types of fibers contribute to posttraumatic hyperalgesia at the skin level, as studies show. Their deficiencies likely impact on posttraumatic hyperalgesia at the skin level and, probably, also at the skeletal level.
conclusionIt is hypothesised that deep dull aching in an acute diabetic Charcot foot may represent faulty posttraumatic hyperalgesia involving cutaneous and skeletal tissues.
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