ArticlePloS one2013
Integrative study of physiological changes associated with bacterial infection in Pacific oyster larvae.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 99 citations in OpenAlex.
- Bacterial Communities Across the Production Chain of a Pacific Oyster (Pathogens (Basel, Switzerland) · 2026Article
- Range-Wide Genetic Population Structure and Environmental Adaptation in the Eastern Oyster (Crassostrea virginica) Provides Insight for Aquaculture.Molecular ecology · 2026Article
- Different responses of larval fatty acid profiles to cryopreservation in two commercially important bivalves.Scientific reports · 2024Article
- The ProbioticMicroorganisms · 2023Article
- Lipidomic insights into the immune response and pearl formation in transplanted pearl oysterFrontiers in immunology · 2022Article
- Can only one physiological trait determinate the adverse effect of green fluorescent protein (GFP) incorporation on Vibrio virulence?Applied microbiology and biotechnology · 2021Article
- Dynamic Immune Response to Vibriosis in Pacific OysterMicroorganisms · 2021Article
- Temporal proteomic profiling reveals insight into critical developmental processes and temperature-influenced physiological response differences in a bivalve mollusc.BMC genomics · 2020Article
- Contrasting Immunomodulatory Effects of Probiotic and Pathogenic Bacteria on Eastern Oyster,Vaccines · 2020Article
- Comparative genomic analysis of Vibrios yields insights into genes associated with virulence towards C. gigas larvae.BMC genomics · 2020Article
- Larval Geoduck (Panopea generosa) Proteomic Response to Ciliates.Scientific reports · 2020Article
- Identification and Genome Analysis ofPathogens (Basel, Switzerland) · 2020Article
- Autophagy Dually Induced by AMP Surplus and Oxidative Stress Enhances Hemocyte Survival and Bactericidal Capacity via AMPK Pathway inFrontiers in cell and developmental biology · 2020Article
- Mechanistic molecular responses of the giant clam Tridacna crocea to Vibrio coralliilyticus challenge.PloS one · 2020Article
- Article
- Metabolomics Study of Immune Responses of New Zealand Greenshell™ Mussels (Perna canaliculus) Infected with Pathogenic Vibrio sp.Marine biotechnology (New York, N.Y.) · 2018Article
- Metabolism of the Pacific oyster,Biology open · 2018Article
- Complete Genome Sequence of a Bacteriophage, pVco-5, That InfectsGenome announcements · 2018Article
- Three Draft Genome Sequences ofGenome announcements · 2017Article
- Complete Genome Sequence ofGenome announcements · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial infections are common in bivalve larvae and can lead to significant mortality, notably in hatcheries. Numerous studies have identified the pathogenic bacteria involved in such mortalities, but physiological changes associated with pathogen exposure at larval stage are still poorly understood. In the present study, we used an integrative approach including physiological, enzymatic, biochemical, and molecular analyses to investigate changes in energy metabolism, lipid remodelling, cellular stress, and immune status of Crassostrea gigas larvae subjected to experimental infection with the pathogenic bacteria Vibrio coralliilyticus.
findingsOur results showed that V. coralliilyticus exposure induced (1) limited but significant increase of larvae mortality compared with controls, (2) declined feeding activity, which resulted in energy status changes (i.e. reserve consumption, β-oxidation, decline of metabolic rate), (3) fatty acid remodeling of polar lipids (changes in phosphatidylinositol and lysophosphatidylcholine composition`, non-methylene-interrupted fatty acids accumulation, lower content of major C20 polyunsaturated fatty acids as well as activation of desaturases, phospholipase and lipoxygenase), (4) activation of antioxidant defenses (catalase, superoxide dismutase, peroxiredoxin) and cytoprotective processes (heat shock protein 70, pernin), and (5) activation of the immune response (non-self recognition, NF-κκ signaling pathway, haematopoiesis, eiconosoids and lysophosphatidyl acid synthesis, inhibitor of metalloproteinase and antimicrobial peptides).
conclusionOverall, our results allowed us to propose an integrative view of changes induced by a bacterial infection in Pacific oyster larvae, opening new perspectives on the response of marine bivalve larvae to infections.
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