ArticlePloS one2013
Metabolomics tools for describing complex pesticide exposure in pregnant women in Brittany (France).
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Trial
- Prenatal Organophosphate Pesticide Exposure and Targeted Maternal Pregnancy Metabolomic Profiles in the NYU CHES Cohort.Environmental science & technology · 2025Article
- An untargeted metabolome-wide association study of maternal perinatal tobacco smoking in newborn blood spots.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Effects of exposure to trihalomethanes in swimming pool waters on metabolomics profile: a randomized parallel design trial.Journal of environmental health science & engineering · 2024Article
- Implementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure.Molecular omics · 2024Review
- Untargeted serum metabolic profiling of diabetes mellitus among Parkinson's disease patients.NPJ Parkinson's disease · 2024Article
- Characterization of multiple pesticide exposure in pregnant women in Brittany, France.Journal of exposure science & environmental epidemiology · 2024Article
- Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study.Environmental health perspectives · 2023Article
- Investigating the relationship between non-occupational pesticide exposure and metabolomic biomarkers.Frontiers in public health · 2023Article
- Metabolome-wide association study of the relationship between chlorpyrifos exposure and first trimester serum metabolite levels in pregnant Thai farmworkers.Environmental research · 2022Article
- Characterizing the follicular fluid metabolome: quantifying the correlation across follicles and differences with the serum metabolome.Fertility and sterility · 2022Article
- Protective Effect of Nebivolol against Oxidative Stress Induced by Aristolochic Acids in Endothelial Cells.Toxins · 2022Article
- Pesticide residue intake from fruits and vegetables and alterations in the serum metabolome of women undergoing infertility treatment.Environment international · 2022Article
- Operationalizing the Exposome Using Passive Silicone Samplers.Current pollution reports · 2022Review
- Commentary: Novel strategies and new tools to curtail the health effects of pesticides.Environmental health : a global access science source · 2021Article
- Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.Endocrine reviews · 2021Review
- High-Resolution Metabolomic Assessment of Pesticide Exposure in Central Valley, California.Chemical research in toxicology · 2021Article
- Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants.Biomolecules · 2020Review
- Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world.Metabolomics : Official journal of the Metabolomic Society · 2020Review
- Metabolomics coupled with pathway analysis characterizes metabolic changes in response to BDE-3 induced reproductive toxicity in mice.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of pesticides and the related environmental contaminations can lead to human exposure to various molecules. In early-life, such exposures could be responsible for adverse developmental effects. However, human health risks associated with exposure to complex mixtures are currently under-explored.
objectiveTHIS PROJECT AIMS AT ANSWERING THE FOLLOWING QUESTIONS: What is the influence of exposures to multiple pesticides on the metabolome? What mechanistic pathways could be involved in the metabolic changes observed?
methodsBased on the PELAGIE cohort (Brittany, France), 83 pregnant women who provided a urine sample in early pregnancy, were classified in 3 groups according to the surface of land dedicated to agricultural cereal activities in their town of residence. Nuclear magnetic resonance-based metabolomics analyses were performed on urine samples. Partial Least Squares Regression-Discriminant Analysis (PLS-DA) and polytomous regressions were used to separate the urinary metabolic profiles from the 3 exposure groups after adjusting for potential confounders.
resultsThe 3 groups of exposure were correctly separated with a PLS-DA model after implementing an orthogonal signal correction with pareto standardizations (R2 = 90.7% and Q2 = 0.53). After adjusting for maternal age, parity, body mass index and smoking habits, the most statistically significant changes were observed for glycine, threonine, lactate and glycerophosphocholine (upward trend), and for citrate (downward trend).
conclusionThis work suggests that an exposure to complex pesticide mixtures induces modifications of metabolic fingerprints. It can be hypothesized from identified discriminating metabolites that the pesticide mixtures could increase oxidative stress and disturb energy metabolism.
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