Trial reportPloS one2013
Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Trial
- Dopamine transporter gene (Pain reports · 2026Article
- Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice.BMC complementary medicine and therapies · 2025Article
- Influence ofJournal of pharmacy & bioallied sciences · 2020Article
- Validity of the cold pressor test and pain sensitivity questionnaire via online self-administration.PloS one · 2020Article
- Psychological and Genetic Predictors of Pain Tolerance.Clinical and translational science · 2019Article
- The risk for problematic opioid use in chronic pain: What can we learn from studies of pain and reward?Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Pharmacological Insights into the Use of Apomorphine in Parkinson's Disease: Clinical Relevance.Clinical drug investigation · 2018Review
- Methylphenidate attenuates the response to cold pain but not to aversive auditory stimuli in healthy human: a double-blind randomized controlled study.Pain reports · 2017Article
- ADHD risk alleles associated with opiate addiction: study of addicted parents and their children.Pediatric research · 2016Article
- Review
- Manipulating the Placebo Response in Experimental Pain by Altering Doctor's Performance Style.Frontiers in psychology · 2016Article
- Experimental comparison of parametric versus nonparametric analyses of data from the cold pressor test.The journal of pain · 2015Article
- Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter gene. Healthy volunteers (n = 105) participated in this randomized double-blind, placebo-controlled, cross-over trial. Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) were evaluated before and for up to 120 min after the administration of 1.5 mg apomorphine/placebo. A polymorphism (3'-UTR 40-bp VNTR) within the dopamine transporter gene (SLC6A3) was investigated. Apomorphine had an effect only on tolerance to cold pain, which consisted of an initial decrease and a subsequent increase in tolerance. An association was found between the enhancing effect of apomorphine on pain tolerance (120 min after its administration) and the DAT-1 polymorphism. Subjects with two copies of the 10-allele demonstrated significantly greater tolerance prolongation than the 9-allele homozygote carriers and the heterozygote carriers (p = 0.007 and p = 0.003 in comparison to the placebo, respectively). In conclusion, apomorphine administration produced a decrease followed by a genetically associated increase in cold pain tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.