ReviewMicrobiology (Reading, England)2013
Cyclic di-GMP signalling and the regulation of bacterial virulence.
Review in Microbiology (Reading, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 96 citations in OpenAlex.
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- Genetic Dissection of Cyclic di-GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption.Microbial biotechnology · 2025Article
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- Vitamin D and vitamin K1 as novel inhibitors of biofilm in Gram-negative bacteria.BMC microbiology · 2024Article
- Roles and Regulation of Quorum Sensing of Acidophiles in Bioleaching: A Review.Microorganisms · 2024Review
- Quorum Quenching with a Diffusible Signal Factor Analog inPathogens (Basel, Switzerland) · 2023Article
- Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems.Cell communication and signaling : CCS · 2023Review
- Comparative genome analysis unravels pathogenicity of Xanthomonas albilineans causing sugarcane leaf scald disease.BMC genomics · 2022Article
- Factors mediatingCurrent research in microbial sciences · 2022Review
- Article
- Spore-Associated Proteins Involved in c-di-GMP Synthesis and Degradation of Bacillus anthracis.Journal of bacteriology · 2021Article
- Bacteriophage-mediated interference of the c-di-GMP signalling pathway in Pseudomonas aeruginosa.Microbial biotechnology · 2021Article
- Motility, Adhesion and c-di-GMP Influence the Endophytic Colonization of Rice byMicroorganisms · 2021Article
- Biofilms-Impacts on Human Health and Its Relevance to Space Travel.Microorganisms · 2020Review
- Mechanistic insights into host adaptation, virulence and epidemiology of the phytopathogen Xanthomonas.FEMS microbiology reviews · 2020Review
- Secondary Effects of Antibiotics on Microbial Biofilms.Frontiers in microbiology · 2020Review
- Interspecies and Intraspecies Signals Synergistically Regulate Lysobacter enzymogenes Twitching Motility.Applied and environmental microbiology · 2019Article
- Bordetella bronchiseptica Diguanylate Cyclase BdcA Regulates Motility and Is Important for the Establishment of Respiratory Infection in Mice.Journal of bacteriology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Signal transduction pathways involving the second messenger cyclic di-GMP [bis-(3'-5')-cyclic di-guanosine monophosphate] occur widely in bacteria where they act to link perception of environmental or intracellular cues and signals to specific alterations in cellular function. Such alterations can contribute to bacterial lifestyle transitions including biofilm formation and virulence. The cellular levels of the nucleotide are controlled through the opposing activities of diguanylate cyclases (DGCs) and phosphodiesterases (PDEs). The GGDEF domain of DGCs catalyses the synthesis of cyclic di-GMP from GTP, whereas EAL or HD-GYP domains in different classes of PDE catalyse cyclic di-GMP degradation to pGpG and GMP. We are now beginning to understand how alterations in cyclic di-GMP exert a regulatory action through binding to diverse receptors or effectors that include a small 'adaptor' protein domain called PilZ, transcription factors and riboswitches. The regulatory action of enzymically active cyclic di-GMP signalling proteins is, however, not restricted to an influence on the level of nucleotide. Here, I will discuss our recent findings that highlight the role that protein-protein interactions involving these signalling proteins have in regulating functions that contribute to bacterial virulence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.