Evidence map›Paper›PMID 23704681›Full record

SynthesisDiabetes care2013

Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis.

Keiichi Kodama, Damon Tojjar, Satoru Yamada, Kyoko Toda, Chirag J Patel, Atul J Butte

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03864562 (Gastric Emptying in Non-diabetic Individuals With Black African/Caribbean Heritage - Implications for the Pathogenesis of Type 2 Diabetes), which is not on this map. Cited by 366 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
366citing papers in PubMed, 5 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03864562 completednot on this mapstarted 2019, after this paper: background citation

Gastric Emptying in Non-diabetic Individuals With Black African/Caribbean Heritage - Implications for the Pathogenesis of Type 2 Diabetes

TypeobservationalSponsorUniversity of NottinghamRan2019 to 2023Enrolled56ConditionsDiabetes Mellitus, Type 2
3 · Its place in the literature

Who cites it

366 citing papers in PubMed, 5 syntheses or guidelines pooled it, 592 citations in OpenAlex.

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  4. Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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306 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Keiichi KodamaDivision of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA. kkodama@stanford.edu
Damon Tojjar
Satoru Yamada
Kyoko Toda
Chirag J Patel
Atul J Butte
Lucile Packard Children's Hospital · USKitasato Institute Hospital · JPKitasato University · JPScania (Sweden) · SEStanford University · US

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Integrating Microarray and Proteomic Data by Ontology-based AnnotationR01LM009719 · NLM · STANFORD UNIVERSITY · PI BUTTE, ATUL J · 2008 to 2011
$1.1M
NLM NIH HHS R01 LM009719NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

objectiveHuman blood glucose levels have likely evolved toward their current point of stability over hundreds of thousands of years. The robust population stability of this trait is called canalization. It has been represented by a hyperbolic function of two variables: insulin sensitivity and insulin response. Environmental changes due to global migration may have pushed some human subpopulations to different points of stability. We hypothesized that there may be ethnic differences in the optimal states in the relationship between insulin sensitivity and insulin response. RESEARCH DESIGN AND

methodsWe identified studies that measured the insulin sensitivity index (SI) and acute insulin response to glucose (AIRg) in three major ethnic groups: Africans, Caucasians, and East Asians. We identified 74 study cohorts comprising 3,813 individuals (19 African cohorts, 31 Caucasian, and 24 East Asian). We calculated the hyperbolic relationship using the mean values of SI and AIRg in the healthy cohorts with normal glucose tolerance.

resultsWe found that Caucasian subpopulations were located around the middle point of the hyperbola, while African and East Asian subpopulations are located around unstable extreme points, where a small change in one variable is associated with a large nonlinear change in the other variable.

conclusionsOur findings suggest that the genetic background of Africans and East Asians makes them more and differentially susceptible to diabetes than Caucasians. This ethnic stratification could be implicated in the different natural courses of diabetes onset.

Indexed as

Asian PeopleBlack PeopleHumansInsulinInsulin ResistanceWhite PeopleInsulin

Identifiers

PMID23704681
PMCPMC3661854
OpenAlexW2067663978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.