ArticleJournal of cell science2013
A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration.
Article in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Moesin integrates cortical and lamellar actin networks during Drosophila macrophage migration.Nature communications · 2025Article
- Evolution of insect innate immunity through domestication of bacterial toxins.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
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- Toward a Consensus in the Repertoire of Hemocytes Identified inFrontiers in cell and developmental biology · 2021Article
- Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution.PLoS biology · 2019Article
- Drosophila Embryonic Hemocytes Produce Laminins to Strengthen Migratory Response.Cell reports · 2017Article
- Mechanisms and in vivo functions of contact inhibition of locomotion.Nature reviews. Molecular cell biology · 2017Review
- Macrophages and cellular immunity in Drosophila melanogaster.Seminars in immunology · 2015Review
- Induction of focal adhesions and motility in Drosophila S2 cells.Molecular biology of the cell · 2014Article
- Drosophila blood cell chemotaxis.Current opinion in cell biology · 2014Review
- Drosophila as a model for the two myeloid blood cell systems in vertebrates.Experimental hematology · 2014Article
- Inducible defenses stay up late: temporal patterns of immune gene expression in Tenebrio molitor.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Throughout embryonic development, macrophages not only act as the first line of defence against infection but also help to sculpt organs and tissues of the embryo by removing dead cells and secreting extracellular matrix components. Key to their function is the ability of embryonic macrophages to migrate and disperse throughout the embryo. Despite these important developmental functions, little is known about the molecular mechanisms underlying embryonic macrophage migration in vivo. Integrins are key regulators of many of the adult macrophage responses, but their role in embryonic macrophages remains poorly characterized. Here, we have used Drosophila macrophages (haemocytes) as a model system to address the role of integrins during embryonic macrophage dispersal in vivo. We show that the main βPS integrin, myospheroid, affects haemocyte migration in two ways; by shaping the three-dimensional environment in which haemocytes migrate and by regulating the migration of haemocytes themselves. Live imaging revealed a requirement for myospheroid within haemocytes to coordinate the microtubule and actin dynamics, and to enable haemocyte developmental dispersal, contact repulsion and inflammatory migration towards wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.