Evidence map›Paper›PMID 23704217›Full record

ReviewCirculation research2013

Platelets as cellular effectors of inflammation in vascular diseases.

Matthew T Rondina, Andrew S Weyrich, Guy A Zimmerman

Open access · bronzeAbstract readReview
In one paragraph

Review in Circulation research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 1 pooled it
21.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 1 synthesis or guideline pooled it, 308 citations in OpenAlex.

  1. Pooled it
  2. Platelet count polygenic scores may modify the effect of aspirin in primary prevention of dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Attachment orientation and platelet activity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025
    Article
  12. Review
  13. Observational
  14. Article
  15. Review
  16. Platelet-Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew T RondinaDepartment of Medicine and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
Andrew S Weyrich
Guy A Zimmerman
University of Utah · US

Funding

UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
Translational Research Skills Development CoreU54HL112311 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2012 to 2016
$12.9M
TRANSLATIONAL EVENTS IN PLATELETSR01HL066277 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2001 to 2012
$3.8M
Molecular Interactions of Myeloid Cells with EndotheliumR37HL044525 · NHLBI · UNIVERSITY OF UTAH · PI ZIMMERMAN, GUY A. · 2004 to 2013
$3.5M
Novel Thrombotic & Inflammatory Mechanisms of Venous Thromboembolism in ElderlyR01HL092746 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2007 to 2010
$2.0M
Novel Activities of Platelets in Acute Lung InjuryR01HL091754 · NHLBI · UNIVERSITY OF UTAH · PI WEYRICH, ANDREW S · 2008 to 2011
$1.5M
New Pathways in Thrombosis and Inflammation Mediated by Semaphorin-Plexin SignaliRC1HL100121 · NHLBI · UNIVERSITY OF UTAH · PI ZIMMERMAN, GUY A. · 2009 to 2010
$997k
Novel Platelet Functions in Sepsis and Venous ThromboembolismK23HL092161 · NHLBI · UNIVERSITY OF UTAH · PI RONDINA, MATTHEW THOMAS · 2009 to 2013
$775k
NCRR NIH HHS UL1 RR025764NCRR NIH HHS ULI-RR025764NHLBI NIH HHS HL12311NHLBI NIH HHS K23 HL092161NHLBI NIH HHS K23HL092161NHLBI NIH HHS R01 HL066277NHLBI NIH HHS R01HL066277NHLBI NIH HHS R01 HL091754NHLBI NIH HHS R01HL091754NHLBI NIH HHS R01 HL092746NHLBI NIH HHS R01HL092746NHLBI NIH HHS R01HL100121NHLBI NIH HHS R37 HL044525NHLBI NIH HHS R37HL044525NHLBI NIH HHS RC1 HL100121NHLBI NIH HHS U54 HL112311
6 · The paper itself

Abstract

Platelets are chief effector cells in hemostasis. In addition, they are multifaceted inflammatory cells with functions that span the continuum from innate immune responses to adaptive immunity. Activated platelets have key thromboinflammatory activities in a variety of vascular disorders and vasculopathies. Recently identified inflammatory and immune activities provide insights into the biology of these versatile blood cells that are directly relevant to human vascular diseases.

Indexed as

Blood PlateletsHumansPlatelet ActivationThrombosisVascular DiseasesVasculitisimmune responsesinflammationplateletsvasculopathyvessel diseases

Identifiers

PMID23704217
PMCPMC3738064
OpenAlexW2138566208

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.