ArticleHepatology (Baltimore, Md.)2013
Evaluating progression of liver disease from repeat liver biopsies in children with chronic hepatitis C: a retrospective study.
Article in Hepatology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.Hepatology (Baltimore, Md.) · 2020Guideline
- 2017 KASL clinical practice guidelines management of hepatitis C: Treatment of chronic hepatitis C.Clinical and molecular hepatology · 2018Guideline
- KASL clinical practice guidelines: management of hepatitis C.Clinical and molecular hepatology · 2016Guideline
- KASL clinical practice guidelines: management of hepatitis C.Clinical and molecular hepatology · 2014Guideline
- The challenge of treating hepatitis C virus infection in children with comorbidities.European journal of pediatrics · 2025Article
- Testing Infants and Children With Perinatal Exposure to Hepatitis C Virus.American family physician · 2024Article
- Direct-Acting Antiviral Agents in Prevention of Maternal-Fetal Transmission of Hepatitis C Virus in Pregnancy.Pathogens (Basel, Switzerland) · 2024Review
- CDC's New Hepatitis C Virus Testing Recommendations for Perinatally Exposed Infants and Children: A Step Towards Hepatitis C Elimination.Journal of women's health (2002) · 2024Article
- Updated Clinical Guidelines on the Management of Hepatitis C Infection in Children.Pathogens (Basel, Switzerland) · 2024Review
- CDC Recommendations for Hepatitis C Testing Among Perinatally Exposed Infants and Children - United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023Article
- Liver biopsy for assessment of chronic liver diseases: a synopsis.Clinical and experimental medicine · 2023Review
- Adolescent Hepatitis C: Prevalence, Impact, and Management Challenges.Adolescent health, medicine and therapeutics · 2021Review
- Management of hepatitis C in children and adolescents during COVID-19 pandemic.World journal of hepatology · 2020Review
- Ledipasvir-Sofosbuvir for 12 Weeks in Children 3 to <6 Years Old With Chronic Hepatitis C.Hepatology (Baltimore, Md.) · 2020Article
- Advanced liver disease in Russian children and adolescents with chronic hepatitis C.Journal of viral hepatitis · 2019Article
- Liver steatosis in children with chronic hepatitis B and C: Prevalence, predictors, and impact on disease progression.Medicine · 2017Observational
- Disease progression in Chinese patients with hepatitis C virus RNA-positive infection via blood transfusion.Experimental and therapeutic medicine · 2016Article
- Vertically acquired hepatitis C virus infection: Correlates of transmission and disease progression.World journal of gastroenterology · 2016Review
- [The guideline of prevention and treatment for hepatitis C: a 2015 update].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2015Article
- Is liver biopsy still needed in children with chronic viral hepatitis?World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
unlabelledClinical and histologic progression of liver disease in untreated children with chronic hepatitis C virus (HCV) infection is poorly documented. The aim of this retrospective study was to characterize changes in liver histology over time in a cohort of HCV-infected children who had more than one liver biopsy separated by over 1 year. Forty-four untreated children without concurrent liver diseases, who had repeat liver biopsies at eight U.S.-based medical centers, were included. Biopsies were scored by a single pathologist for inflammation, fibrosis, and steatosis and were correlated with demographic data including age at biopsy, time from infection to biopsies, and laboratory values such as serum alanine aminotransferase (ALT). Mode of transmission was vertical in 25 (57%) and from transfusions in 17 children (39%). Genotype 1 was present in 30/35 (84%) children. The mean age at first and final biopsy was 8.6 and 14.5 years, respectively, and the mean interval between biopsies was 5.8 ± 3.5 years. Duration of infection to biopsy was 7.7 and 13.5 years, respectively. Laboratory values did not change significantly between the biopsies. Inflammation was minimal in about 50% at both timepoints. Fibrosis was absent in 16% in both biopsies, limited to portal/periportal in 73% in the first biopsy, and 64% in the final biopsy. Between the two biopsies, the proportion of patients with bridging fibrosis/cirrhosis increased from 11% to 20% (P = 0.005).
conclusionAlthough in aggregate this cohort did not show significant histologic progression of liver disease over 5 years, 29.5% (n = 13) of children showed an increase in severity of fibrosis. These findings may have long-term implications for the timing of follow-up biopsies and treatment decisions.
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