ArticleThe Journal of clinical endocrinology and metabolism2013
Calcium and vitamin D intake and mortality: results from the Canadian Multicentre Osteoporosis Study (CaMos).
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis.European journal of epidemiology · 2021Pooled it
- Dietary calcium intake and mortality risk from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies.BMC medicine · 2014Pooled it
- Vitamin D intake and all-cause and cause-specific mortality in Japanese men and women: the Japan Public Health Center-based prospective study.European journal of epidemiology · 2023Article
- Mendelian randomisation study of the relationship between vitamin D and risk of glioma.Scientific reports · 2018Article
- Dietary Calcium Intake in Sample of School Age Children in City of Rabat, Morocco.Journal of nutrition and metabolism · 2018Article
- Self-Report Dietary Assessment Tools Used in Canadian Research: A Scoping Review.Advances in nutrition (Bethesda, Md.) · 2017Article
- Food Fortification and Supplement Use-Are There Health Implications?Critical reviews in food science and nutrition · 2016Review
- Calcium intake: good for the bones but bad for the heart? An analysis of clinical studies.Archives of endocrinology and metabolism · 2016Review
- Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review.International journal of endocrinology · 2015Review
- Fracture history in osteoporosis: risk factors and its effect on quality of life.Balkan medical journal · 2014Article
- Cross-sectional analysis of calcium intake for associations with vascular calcification and mortality in individuals with type 2 diabetes from the Diabetes Heart Study.The American journal of clinical nutrition · 2014Article
- Calcium supplementation: is protecting against osteoporosis counter to protecting against cardiovascular disease?Current osteoporosis reports · 2014Review
- Clinical practice. Calcium supplements and fracture prevention.The New England journal of medicine · 2013Review
- Is plasma pentadecanoic acid a reasonable biomarker of dairy consumption?Journal of the American Heart Association · 2013Article
- Bone mineral density and diet of teachers of College of Home Economics at Lahore.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
contextCalcium and vitamin D are recommended for bone health, but there are concerns about adverse risks. Some clinical studies suggest that calcium intake may be cardioprotective, whereas others report increased risk associated with calcium supplements. Both low and high serum levels of 25-hydroxyvitamin D have been associated with increased mortality.
objectiveThe purpose of this study was to determine the association between total calcium and vitamin D intake and mortality and heterogeneity by source of intake.
designThe Canadian Multicentre Osteoporosis Study cohort is a population-based longitudinal cohort with a 10-year follow-up (1995-2007).
settingThis study included randomly selected community-dwelling men and women.
participantsA total of 9033 participants with nonmissing calcium and vitamin D intake data and follow-up were studied. EXPOSURE: Total calcium intake (dairy, nondairy food, and supplements) and total vitamin D intake (milk, yogurt, and supplements) were recorded. OUTCOME: The outcome variable was all-cause mortality.
resultsThere were 1160 deaths during the 10-year period. For women only, we found a possible benefit of higher total calcium intake, with a hazard ratio of 0.95 (95% confidence interval, 0.89-1.01) per 500-mg increase in daily calcium intake and no evidence of heterogeneity by source; use of calcium supplements was also associated with reduced mortality, with hazard ratio of 0.78 (95% confidence interval, 0.66-0.92) for users vs nonusers with statistically significant reductions remaining among those with doses up to 1000 mg/d. These associations were not modified by levels of concurrent vitamin D intake. No definitive associations were found among men.
conclusionsCalcium supplements, up to 1000 mg/d, and increased dietary intake of calcium may be associated with reduced risk of mortality in women. We found no evidence of mortality benefit or harm associated with vitamin D intake.
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