ArticleThe Journal of biological chemistry2013
Structure of the Chlamydia trachomatis immunodominant antigen Pgp3.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Risk factors associated with IgG seropersistence toEpidemiology and infection · 2025Article
- Regulation of chlamydial spreading from the small intestine to the large intestine by IL-22-producing CD4Infection and immunity · 2024Article
- Antibody responses toFrontiers in cellular and infection microbiology · 2024Article
- Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans.Infection and immunity · 2023Article
- A Machine Learning-Based Analytic Pipeline Applied to Clinical and Serum IgG Immunoproteome Data To Predict Chlamydia trachomatis Genital Tract Ascension and Incident Infection in Women.Microbiology spectrum · 2023Article
- Protective Immunity againstInternational journal of molecular sciences · 2023Article
- Article
- Tryptophan residue of plasmid-encoded Pgp3 is important forFrontiers in microbiology · 2023Article
- Plasmid-mediated virulence inFrontiers in cellular and infection microbiology · 2023Review
- Reduced Endometrial Ascension and Enhanced Reinfection Associated With Immunoglobulin G Antibodies to Specific Chlamydia trachomatis Proteins in Women at Risk for Chlamydia.The Journal of infectious diseases · 2022Article
- Efficacy of Pgp3 vaccination forFrontiers in immunology · 2022Article
- Chlamydia overcomes multiple gastrointestinal barriers to achieve long-lasting colonization.Trends in microbiology · 2021Review
- Article
- The Nature and Extent of Plasmid Variation inMicroorganisms · 2020Article
- Effects of Hydrodynamic Interactions on the Near-Surface Diffusion of Spheroidal Molecules.ACS omega · 2019Article
- The multiple functions of the numerousMicrobial cell (Graz, Austria) · 2019Review
- The Plasmid-Encoded pGP3 PromotesInfection and immunity · 2019Article
- The Structural Integrity of Plasmid-Encoded Pgp3 Is Essential for Induction of Hydrosalpinx byFrontiers in cellular and infection microbiology · 2019Article
- Article
- Chlamydia Spreading from the Genital Tract to the Gastrointestinal Tract - A Two-Hit Hypothesis.Trends in microbiology · 2018Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease. Left untreated, it can lead to ectopic pregnancy, pelvic inflammatory disease, and infertility. Here we present the structure of the secreted C. trachomatis protein Pgp3, an immunodominant antigen and putative virulence factor. The ∼84-kDa Pgp3 homotrimer, encoded on a cryptic plasmid, consists of globular N- and C-terminal assemblies connected by a triple-helical coiled-coil. The C-terminal domains possess folds similar to members of the TNF family of cytokines. The closest Pgp3 C-terminal domain structural homologs include a lectin from Burkholderia cenocepacia, the C1q component of complement, and a portion of the Bacillus anthracis spore surface protein BclA, all of which play roles in bioadhesion. The N-terminal domain consists of a concatenation of structural motifs typically found in trimeric viral proteins. The central parallel triple-helical coiled-coil contains an unusual alternating pattern of apolar and polar residue pairs that generate a rare right-handed superhelical twist. The unique architecture of Pgp3 provides the basis for understanding its role in chlamydial pathogenesis and serves as the platform for its optimization as a potential vaccine antigen candidate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.