ArticleReproductive sciences (Thousand Oaks, Calif.)2013
Epigallocatechin-3-gallate reduces myometrial infiltration, uterine hyperactivity, and stress levels and alleviates generalized hyperalgesia in mice induced with adenomyosis.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Research Advances in Adenomyosis-Related Signaling Pathways and Promising Targets.Biomolecules · 2024Review
- An Appraisal of the Tissue Injury and Repair (TIAR) Theory on the Pathogenesis of Endometriosis and Adenomyosis.Biomolecules · 2023Review
- Review
- The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis.Journal of clinical medicine · 2023Review
- Beneficial Effects of Green Tea Catechins on Female Reproductive Disorders: A Review.Molecules (Basel, Switzerland) · 2021Review
- Shi Xiao San ameliorates the development of adenomyosis in an ICR mouse model.Experimental and therapeutic medicine · 2020Article
- Animal Models of Adenomyosis.Seminars in reproductive medicine · 2020Review
- Adenomyosis: Mechanisms and Pathogenesis.Seminars in reproductive medicine · 2020Review
- Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model.Drug design, development and therapy · 2017Article
- Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence.Reproductive biology and endocrinology : RB&E · 2016Article
- Stress management affects outcomes in the pathophysiology of an endometriosis model.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Possible Loss of GABAergic Inhibition in Mice With Induced Adenomyosis and Treatment With Epigallocatechin-3-Gallate Attenuates the Loss With Improved Hyperalgesia.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Possible therapeutic effect of trilostane in rodent models of inflammation and nociception.Current therapeutic research, clinical and experimental · 2013Article
- Protective Effects of Resveratrol Against Adenomyosis in a Mouse Model.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an effort to search for novel therapeutics for adenomyosis, we sought to determine whether treatment with epigallocatechin-3-gallate (EGCG) would suppress the myometrial infiltration, improve pain behavior, lower stress level, and reduce uterine contractility in a mice model of adenomyosis. Adenomyosis was induced in 28 female ICR mice neonatally dosed with tamoxifen, while another 12 (group C) were dosed with solvent only, which served as a blank control. Starting from 4 weeks after birth, hot plate test was administrated to all mice every 4 weeks. At the 16th week, all mice induced with adenomyosis were randomly divided into 3 groups: low-dose EGCG (5 mg/kg), high-dose EGCG (50 mg/kg), and untreated. Group C received no treatment. After 3 weeks of treatment, the hot plate test was administered again, a blood sample was taken to measure the plasma corticosterone level by enzyme-linked immunosorbent assay, and then all mice were sacrificed. The depth of myometrial infiltration and uterine contractility were also evaluated. We found that the induction of adenomyosis resulted in progressive generalized hyperalgesia, along with elevated amplitude and frequency of uterine contractions as well as elevated plasma corticosterone levels. The EGCG treatment dose dependently suppressed myometrial infiltration, improved generalized hyperalgesia, reduced uterine contractility, and lowered plasma corticosterone levels. These results suggest that induced adenomyosis causes pain and elevates stress levels in mice. Uterine hyperactivity may contribute to dysmenorrhea in women with adenomyosis who might also have elevated stress level due to pain. The EGCG appears to be a promising compound for treating adenomyosis.
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