ReviewPhotosynthesis research2013
Understanding chloroplast biogenesis using second-site suppressors of immutans and var2.
Review in Photosynthesis research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Plant proteases: guardians of proteome integrity and regulators of protein function.Journal of experimental botany · 2025Article
- Alternaria solani Effector AsCEP20, Essential for Virulence, Targets Potato StFtsH4 Protein to Suppress Plant Disease Resistance.Molecular plant pathology · 2025Article
- Silencing of PepperInternational journal of molecular sciences · 2023Article
- Article
- Abundance of metalloprotease FtsH12 modulates chloroplast development in Arabidopsis thaliana.Journal of experimental botany · 2021Article
- Disruption of carotene biosynthesis leads to abnormal plastids and variegated leaves in Brassica napus.Molecular genetics and genomics : MGG · 2020Article
- A point mutation in the photosystem I P700 chlorophyll a apoprotein A1 gene confers variegation in Helianthus annuus L.Plant molecular biology · 2020Article
- The chloroplast metalloproteases VAR2 and EGY1 act synergistically to regulate chloroplast development in Arabidopsis.The Journal of biological chemistry · 2020Article
- Leaf Variegation and Impaired Chloroplast Development Caused by a Truncated CCT Domain Gene inThe Plant cell · 2019Article
- Extrachloroplastic PP7L Functions in Chloroplast Development and Abiotic Stress Tolerance.Plant physiology · 2019Article
- Reduced expression of the proteolytically inactive FtsH members has impacts on the Darwinian fitness of Arabidopsis thaliana.Journal of experimental botany · 2019Article
- Chloroplast Translation Elongation Factor EF-Tu/SVR11 Is Involved inFrontiers in plant science · 2019Article
- Article
- FtsH Protease in the Thylakoid Membrane: Physiological Functions and the Regulation of Protease Activity.Frontiers in plant science · 2018Review
- Balance between Cytosolic and Chloroplast Translation Affects Leaf Variegation.Plant physiology · 2018Article
- Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis.PLoS genetics · 2017Article
- Lethal albinic seedling, encoding a threonyl-tRNA synthetase, is involved in development of plastid protein synthesis system in rice.Plant cell reports · 2017Article
- Mutations in the ArabidopsisFrontiers in plant science · 2017Article
- Chloroplast Translation Initiation Factors Regulate Leaf Variegation and Development.Plant physiology · 2016Article
- Thylakoid-Bound FtsH Proteins Facilitate Proper Biosynthesis of Photosystem I.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloroplast biogenesis is an essential light-dependent process involving the differentiation of photosynthetically competent chloroplasts from precursors that include undifferentiated proplastids in leaf meristems, as well as etioplasts in dark-grown seedlings. The mechanisms that govern these developmental processes are poorly understood, but entail the coordinated expression of nuclear and plastid genes. This coordination is achieved, in part, by signals generated in response to the metabolic and developmental state of the plastid that regulate the transcription of nuclear genes for photosynthetic proteins (retrograde signaling). Variegation mutants are powerful tools to understand pathways of chloroplast biogenesis, and over the years our lab has focused on immutans (im) and variegated2 (var2), two nuclear gene-induced variegations of Arabidopsis. im and var2 are among the best-characterized chloroplast biogenesis mutants, and they define the genes for plastid terminal oxidase (PTOX) and the AtFtsH2 subunit of the thylakoid FtsH metalloprotease complex, respectively. To gain insight into the function of these proteins, forward and reverse genetic approaches have been used to identify second-site suppressors of im and var2 that replace or bypass the need for PTOX and AtFtsH2 during chloroplast development. In this review, we provide a brief update of im and var2 and the functions of PTOX and AtFtsH2. We then summarize information about second-site suppressors of im and var2 that have been identified to date, and describe how they have provided insight into mechanisms of photosynthesis and pathways of chloroplast development.
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