Evidence map›Paper›PMID 23703033›Full record

ArticleNeuroradiology2013

Prognostic value of brain proton MR spectroscopy and diffusion tensor imaging in newborns with hypoxic-ischemic encephalopathy treated by brain cooling.

G Ancora, C Testa, S Grandi, C Tonon, F Sbravati, S Savini, D N Manners, L L Gramegna, G Tani, E Malucelli and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Ultrasound Predicts White Matter Integrity after Hypothermia Therapy in Neonatal Hypoxic-Ischemic Injury.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019
    Article
  16. Altered plasma-type gelsolin and amyloid-β in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. [Current status of the application ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

G AncoraNeonatal Intensive Care Unit, Department of Mother and Infant Infermi Hospital of Rimini, Rimini, Italy. gina.ancora@auslrn.net.
C TestaMR Functional Unit, Department of Biomedical and Neuromotor Sciences University of Bologna, Bologna, Italy.
S GrandiNeonatology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy.
C TononMR Functional Unit, Department of Biomedical and Neuromotor Sciences University of Bologna, Bologna, Italy.
F SbravatiNeonatology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy.
S SaviniNeonatology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy.
D N MannersMR Functional Unit, Department of Biomedical and Neuromotor Sciences University of Bologna, Bologna, Italy.
L L GramegnaMR Functional Unit, Department of Biomedical and Neuromotor Sciences University of Bologna, Bologna, Italy.
G TaniRadiology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy.
E MalucelliDepartment of Pharmacy and Biotechnologies, University of Bologna, Bologna, Italy.
L T CorvagliaNeonatology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy.
G FaldellaNeonatology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy.
R LodiMR Functional Unit, Department of Biomedical and Neuromotor Sciences University of Bologna, Bologna, Italy.
University of Bologna · ITOspedale Infermi di Rimini · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMRI, proton magnetic resonance spectroscopy (¹H-MRS), and diffusion tensor imaging (DTI) have been shown to be of great prognostic value in term newborns with moderate-severe hypoxic-ischemic encephalopathy (HIE). Currently, no data are available on ¹H-MRS and DTI performed in the subacute phase after hypothermic treatment. The aim of the present study was to assess their prognostic value in newborns affected by moderate-severe HIE and treated with selective brain cooling (BC).

methodsTwenty infants treated with BC underwent conventional MRI and (1)H-MRS at a mean (SD) age of 8.3 (2.8) days; 15 also underwent DTI. Peak area ratios of metabolites and DTI variables, namely mean diffusivity (MD), axial and radial diffusivity, and fractional anisotropy (FA), were calculated. Clinical outcome was monitored until 2 years of age.

resultsAdverse outcome was observed in 6/20 newborns. Both ¹H-MRS and DTI variables showed higher prognostic accuracy than conventional MRI. N-acetylaspartate/creatine at a basal ganglia localisation showed 100% PPV and 93% NPV for outcome. MD showed significantly decreased values in many regions of white and gray matter, axial diffusivity showed the best predictive value (PPV and NPV) in the genu of corpus callosum (100 and 91%, respectively), and radial diffusivity was significantly decreased in fronto white matter (FWM) and fronto parietal (FP) WM. The decrement of FA showed the best AUC (0.94) in the FPWM.

conclusionSelective BC in HIE neonates does not affect the early and accurate prognostic value of ¹H-MRS and DTI, which outperform conventional MRI.

Indexed as

BiomarkersBrainCryotherapyDiffusion Tensor ImagingFemaleHumansHypoxia-Ischemia, BrainInfant, NewbornMagnetic Resonance ImagingMalePrognosisProtonsReproducibility of ResultsSensitivity and SpecificityTreatment OutcomeBiomarkersProtons

Identifiers

PMID23703033
OpenAlexW1978515359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.