Evidence map›Paper›PMID 23702928›Full record

ReviewNature reviews. Cancer2013

Neuroblastoma: developmental biology, cancer genomics and immunotherapy.

Nai-Kong V Cheung, Michael A Dyer

Abstract readReview
In one paragraph

Review in Nature reviews. Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 484 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
484citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

484 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. [European journal of nuclear medicine and molecular imaging · 2026
    Observational
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424 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nai-Kong V CheungDepartment of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. cheungn@mskcc.org
Michael A Dyer

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Proliferation Control in the Retina: The Rb FamilyR01EY014867 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2003 to 2012
$4.5M
Proliferation and Differentiation of Retinal Stem CellsR01EY018599 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2008 to 2011
$2.5M
Epigenetic Reprogramming of Retinal NeuronsR01EY023619 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2013 to 2017
$2.2M
Molecular Targeted Therapy for RetinoblastomaR01CA168875 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2012 to 2016
$1.8M
Engineering and Evaluation of Human L-Methionase for Cancer TherapyR01CA154754 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI GEORGIOU, GEORGE GEORGIOU, STONE, EVERETT · 2011 to 2014
$1.7M
Phase I Study of Humanized 3F8 Monoclonal Antibody (Hu3F8) in Patients with High-R21CA161978 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHEUNG, NAI-KONG V · 2011 to 2012
$752k
Howard Hughes Medical InstituteNCI NIH HHS CA154754NCI NIH HHS CA161978NCI NIH HHS CA168875NCI NIH HHS CA21765NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA154754NCI NIH HHS R01 CA168875NCI NIH HHS R21 CA161978NEI NIH HHS EY014867NEI NIH HHS EY018599NEI NIH HHS R01 EY014867NEI NIH HHS R01 EY018599NEI NIH HHS R01 EY023619
6 · The paper itself

Abstract

Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously. The future challenge is to apply the knowledge gained to developing risk-based therapies and, ultimately, improving outcome. In this Review we discuss the key discoveries in the developmental biology, molecular genetics and immunology of neuroblastoma, as well as new translational tools for bringing these promising scientific advances into the clinic.

Indexed as

ImmunotherapyAnaplastic Lymphoma KinaseAnimalsCancer VaccinesDNA HelicasesGenomicsHumansMutationNeural CrestNeuroblastomaNuclear ProteinsReceptor Protein-Tyrosine KinasesSympathetic Nervous SystemX-linked Nuclear ProteinAnaplastic Lymphoma KinaseATRX protein, humanCancer VaccinesDNA HelicasesNuclear ProteinsReceptor Protein-Tyrosine KinasesX-linked Nuclear Protein

Identifiers

PMID23702928
PMCPMC4386662

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.