ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Albuminuria is associated with hip fracture risk in older adults: the cardiovascular health study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Association of Increased Urinary Albumin With Risk of Incident Clinical Fracture and Rate of Hip Bone Loss: the Osteoporotic Fractures in Men Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Trial
- Associations of Albuminuria and Metabolic Syndrome Traits With Fracture Risk in Patients With Type 2 Diabetes: A Population-Based Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- The association of microvascular disease and endothelial dysfunction with vertebral trabecular bone mineral density : The MESA study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Increased hip fracture risk in the patients with type 2 diabetes mellitus is correlated with urine albumin-to-creatinine ratio (ACR) and diabetes duration in men.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Prognostic Factors of Hip Fracture in Elderly: A Systematic Review.International journal of preventive medicine · 2024Review
- Proteinuria screening and risk of bone fracture: a retrospective cohort study using a nationwide population-based database.Clinical kidney journal · 2024Article
- Mortality Following Hip Fracture in Older Adults With and Without Coronary Heart Disease.The American journal of medicine · 2023Article
- Age-Related Factors Associated With The Risk of Hip Fracture.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023Review
- Association between urine albumin to creatinine ratio and bone mineral density: a cross-sectional study.Irish journal of medical science · 2022Article
- Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study.Journal of the American Geriatrics Society · 2021Article
- Cardiovascular autonomic nervous system function and hip fracture risk: the Cardiovascular Health Study.Archives of osteoporosis · 2021Article
- Hospitalization Rates in Older Adults With Albuminuria: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Higher albumin:creatinine ratio and lower estimated glomerular filtration rate are potential risk factors for decline of physical performance in the elderly: the Cardiovascular Health Study.Clinical kidney journal · 2019Article
- Proteinuria Is Associated With Increased Risk of Fragility Fracture in Men With or at Risk of HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Article
- Association between low-grade albuminuria and frailty among community-dwelling middle-aged and older people: a cross-sectional analysis from I-Lan Longitudinal Aging Study.Scientific reports · 2016Article
- Systemic markers of microvascular disease and bone mineral density in older adults : The cardiovascular health study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Kidney Function and Fracture Risk: The Atherosclerosis Risk in Communities (ARIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2016Article
- Ratio of urine albumin to creatinine attenuates the association of dementia with hip fracture risk.The Journal of clinical endocrinology and metabolism · 2014Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
unlabelledThe microcirculation plays an important role in bone health. Here, we examine whether albuminuria, a marker of renal microvascular disease, is associated with the risk of hip fracture in older adults (age, 78 years). We find a small independent association in women but not in men.
introductionThe microvascular circulation plays an important role in bone physiology. Two studies of middle-aged adults have found that albuminuria (>30 mg albumin/g creatinine), a disorder of the renal microvasculature, is associated with fracture risk. Here, we examine whether albuminuria is related to hip fracture risk and reduced hip bone mineral density (BMD) in older adults with a mean age of 78 years.
methodsFrom the Cardiovascular Health Study (41 % male), 3,110 adults with albuminuria testing were followed up for incident hip fracture for up to 9.5 years. BMD was performed in a subset of 1,208 participants.
resultsThere were 313 hip fractures during follow-up (7.7 % of men; 11.7 % of women). The incidence rate for men, with and without albuminuria, was 1.43 and 0.93/100 person-years of follow-up (p = 0.02); for women, 1.84 and 1.33 (p = 0.04). After adjustment for osteoporosis-related factors, frailty and falling, a doubling of albuminuria was significantly associated with hip fracture risk in women (hazard ratio, 1.12, 95 % CI, 1.001-1.25), but not in men. In the subcohort with BMD measurement, increased urine albumin levels were significantly associated with decreased total hip BMD in men (-0.009 g calcium/cm(2) (-0.017, -0.001); p = 0.04), but not in women.
conclusionsIn older women, albuminuria is associated with a small, but statistically significant, increased risk of hip fracture independent of other explanatory factors. No such risk appears to be present in men, although their total hip BMD is lower in association with albuminuria.
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