ArticleJournal of perinatology : official journal of the California Perinatal Association2013
Absorption and tolerability of aqueous chlorhexidine gluconate used for skin antisepsis prior to catheter insertion in preterm neonates.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Aqueous chlorhexidine 1% versus 2% for neonatal skin antisepsis: a randomised non-inferiority trial.Archives of disease in childhood. Fetal and neonatal edition · 2021Trial
- One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units.Journal of perinatology : official journal of the California Perinatal Association · 2014Trial
- Environmental exposures in the neonatal intensive care unit impacting neurodevelopmental outcomes for neonates.Pediatric research · 2025Review
- Seeing beyond the obvious: pragmatic skin care guidance for infants 22-24 weeks gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- The use of 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to central venous catheterization in infants: a national survey of the Italian Society of Neonatology.Italian journal of pediatrics · 2025Article
- Efficacy and safety of three antiseptics for neonatal skin disinfection: further evidence for chlorhexidine gluconate.Pediatric research · 2025Article
- Efficacy and safety of three antiseptics for neonatal skin disinfection: a cohort study.Pediatric research · 2025Article
- Epidemiology and Mortality of Invasive Staphylococcus aureus Infections in Hospitalized Infants.JAMA pediatrics · 2025Article
- Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pilot trial.EClinicalMedicine · 2024Article
- Microbiome dysbiosis: a modifiable state and target to prevent Staphylococcus aureus infections and other diseases in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Myelin toxicity of chlorhexidine in zebrafish larvae.Pediatric research · 2023Article
- Global variation in skin injures and skincare practices in extremely preterm infants.World journal of pediatrics : WJP · 2023Article
- Assessment of Alcohol Exposure From Alcohol-Based Disinfectants Among Premature Infants in Neonatal Incubators in Japan.JAMA network open · 2023Article
- Randomized controlled trial on healthy volunteers of pharmacokinetic and antimicrobial activity of a novel hydrogel-containing chlorhexidine dressing to prevent catheter-related bloodstream infection.Frontiers in medicine · 2023Article
- Infection Prevention in the Neonatal Intensive Care Unit.Clinics in perinatology · 2021Review
- The prevalence of antiseptic tolerance genes among staphylococci and enterococci in a pediatric population.Infection control and hospital epidemiology · 2019Article
- Best Practices of Blood Cultures in Low- and Middle-Income Countries.Frontiers in medicine · 2019Review
- The downside of antimicrobial agents for wound healing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Preventive bundles to reduce catheter-associated bloodstream infections in neonatal intensive care.GMS hygiene and infection control · 2018Article
- Skin care practices in newborn nurseries and mother-baby units in Maryland.Journal of perinatology : official journal of the California Perinatal Association · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess chlorhexidine absorption and skin tolerability in premature infants, following skin antisepsis with 2% aqueous chlorhexidine gluconate (CHG) prior to peripherally inserted central catheter (PICC) placement. STUDY
designNeonates less than 32 weeks gestation had skin cleansed with CHG prior to PICC placement. CHG concentrations were measured on serial blood samples. Skin integrity was evaluated for 2 weeks after CHG exposure.
resultTwenty infants were enrolled; median gestational age was 28 2/7 weeks (range 24 3/7 to 31 4/7). Ten infants had detectable serum chlorhexidine concentrations (range 1.6 to 206 ng ml(-1)). Seven of these infants had their highest serum concentration 2 to 3 days following exposure. No CHG-related skin irritation occurred in any infant.
conclusionCHG was detected in the blood of preterm infants receiving CHG skin antisepsis for PICC insertion. Highest serum concentrations occurred 2 to 3 days after exposure. Further investigation is needed to determine the clinical relevance of CHG absorption in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.