SynthesisDiabetologia2013
The association of the mitochondrial DNA OriB variant (16184-16193 polycytosine tract) with type 2 diabetes in Europid populations.
Synthesis in Diabetologia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk.Nature communications · 2026Article
- The Association of Mitochondrial tRNANeuropsychiatric disease and treatment · 2025Article
- Circulating Mitochondrial DNA and Inter-Organelle Contact Sites in Aging and Associated Conditions.Cells · 2022Review
- Article
- Inheritance of mitochondrial DNA in humans: implications for rare and common diseases.Journal of internal medicine · 2020Review
- Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis.American journal of physiology. Endocrinology and metabolism · 2019Review
- Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients.Journal of clinical medicine · 2018Article
- Pathophysiology of Type 2 Diabetes in Koreans.Endocrinology and metabolism (Seoul, Korea) · 2018Review
- Mitochondrial T16189C Polymorphism Is Associated with Metabolic Syndrome in the Mexican Population.Disease markers · 2018Article
- Cisplatin selects short forms of the mitochondrial DNA OriB variant (16184-16193 poly-cytosine tract), which confer resistance to cisplatin.Scientific reports · 2017Article
- Insights into pancreatic β cell energy metabolism using rodent β cell models.Wellcome open research · 2017Article
- Mitochondrial content is central to nuclear gene expression: Profound implications for human health.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?PloS one · 2015Article
- mtDNA G10398A variation provides risk to type 2 diabetes in population group from the Jammu region of India.Meta gene · 2014Article
- Recent advances in the molecular genetics of type 2 diabetes mellitus.World journal of diabetes · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aims/hypothesisThe association between the mitochondrial DNA 16181-16193 polycytosine variant (known as the OriB variant as it maps to the OriB origin of replication) and type 2 diabetes has not been reliably characterised, with studies reporting conflicting results. We report a systematic review of published literature in Europid populations, new data from the Norfolk Diabetes Case-Control Study and a meta-analysis to help quantify this association.
methodsWe performed a systematic review identifying all the studies of the OriB variant and type 2 diabetes in Europid populations published before January 2013. We typed the OriB variant by pyrosequencing and sequencing in the Norfolk Diabetes Case-Control Study, which comprised 5,574 type 2 diabetes cases and 6,950 population-based controls.
resultsOverall, the meta-analysis included eight published studies plus the current new results, with a total of 11,794 type 2 diabetes cases and 14,465 controls. In the Norfolk Diabetes Case-Control Study, the OR for type 2 diabetes for the OriB variant was 1.09 (95% CI 0.96, 1.24). In a combined analysis, the relative risk for type 2 diabetes for the OriB variant in Europid populations was 1.10 (95% CI 1.01, 1.20; p = 0.03) CONCLUSIONS/
interpretationResults from this systematic review and meta-analysis suggest that the mitochondrial DNA OriB variant is modestly associated with an increased risk of type 2 diabetes in Europid populations, with an effect size comparable with that of recently identified variants from genome-wide association studies.
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