ReviewClinical psychology review2013
Neuroticism and common mental disorders: meaning and utility of a complex relationship.
Review in Clinical psychology review, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07433907 (A Prospective, Randomized, Split-Face Pilot Study Comparing the Efficacy of the Institute of Dermatology's Antioxidant Moisturizing Serum in Mild to Moderate Seborrheic Dermatitis), which is not on this map. Cited by 257 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized, Split-Face Pilot Study Comparing the Efficacy of the Institute of Dermatology's Antioxidant Moisturizing Serum in Mild to Moderate Seborrheic Dermatitis
Who cites it
257 citing papers in PubMed, 7 syntheses or guidelines pooled it, 681 citations in OpenAlex.
- Individual differences in emotional reactivity: A multidimensional systematic review across the big five.PloS one · 2026Pooled it
- The shared variance amongst the measures of individual differences and trait EI: a meta-meta-analytic comparison.Frontiers in psychology · 2025Pooled it
- Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2023Pooled it
- Psychological factors for the onset of depression: a meta-analysis of prospective studies.BMJ open · 2021Pooled it
- Gray matter structures associated with neuroticism: A meta-analysis of whole-brain voxel-based morphometry studies.Human brain mapping · 2021Pooled it
- Obesity has limited behavioural overlap with addiction and psychiatric phenotypes.Nature human behaviour · 2020Pooled it
- Mediators linking insecure attachment to eating symptoms: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Assessing Theories of State and Trait Change in Neuroticism and Symptom Improvement in the Unified Protocol.Behavior therapy · 2024Trial
- Perceived stress mediates the relationship between mindfulness and negative affect variability: A randomized controlled trial among middle-aged to older adults.Stress and health : journal of the International Society for the Investigation of Stress · 2019Trial
- Trait-relevant movies amplify neuroticism-associated brain responses.Communications psychology · 2026Article
- Emotional Stability and Emotional Eating in Medical Students: Exploring Indirect Associations Involving Anxiety and Depressive Symptoms.Nutrients · 2026Observational
- Neuroticism, Internalizing Psychopathology, and Affective Reactions to Thought Content in Daily Life.Journal of personality · 2026Article
- When Saying "Yes" Hurts: The Relationship Between Compliance and Psychological Distress Across Cultural Values in China.Behavioral sciences (Basel, Switzerland) · 2026Article
- Personality Heterogeneity Shapes the Neural Organization of Conditioned Threat Learning.Research square · 2026Article
- Physiological Adaptation Buffers Personality-Linked Psychopathology Under High-Altitude Hypoxia.Brain and behavior · 2026Article
- The functional neurobiology of dispositions towards negative emotions.Nature communications · 2026Article
- Symptoms of depression, suicidal ideation, and personality traits in a sample of medical students: a cross-sectional study.BMC psychiatry · 2026Article
- Personality development from early to middle adulthood in the general population and those with mental health difficulties.Scientific reports · 2026Article
- Real-World Meditation App Engagement: Longitudinal Study of the Medito Meditation App.JMIR mHealth and uHealth · 2026Article
197 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Neuroticism's prospective association with common mental disorders (CMDs) has fueled the assumption that neuroticism is an independent etiologically informative risk factor. This vulnerability model postulates that neuroticism sets in motion processes that lead to CMDs. However, four other models seek to explain the association, including the spectrum model (manifestations of the same process), common cause model (shared determinants), state and scar models (CMD episode adds temporary/permanent neuroticism). To examine their validity we reviewed literature on confounding, operational overlap, stability and change, determinants, and treatment effects. None of the models is able to account for (virtually) all findings. The state and scar model cannot explain the prospective association. The spectrum model has some relevance, especially for internalizing disorders. Common causes are most important but the vulnerability model cannot be excluded although confounding of the prospective association by baseline symptoms and psychiatric history is substantial. In fact, some of the findings, such as interactions with stress and the small decay of neuroticism's effect over time, are consistent with the vulnerability model. We describe research designs that discriminate the remaining models and plea for deconstruction of neuroticism. Neuroticism is etiologically not informative yet but useful as an efficient marker of non-specified general risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.