SynthesisHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2013
The lower, the better? : fractional polynomials meta-regression of blood pressure reduction on stroke risk.
Synthesis in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bayesian fractional polynomial approach to quantile regression and variable selection with application in the analysis of blood pressure among US adults.Journal of applied statistics · 2025Article
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Authors and funding
2 authors.
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Abstract
objectiveLowering systolic blood pressure (BP) (SBP) by 10 mmHg or diastolic BP by 5 mmHg using any of the main classes of BP lowering drugs reduces stroke by about a third. The objective of the present study is to determine whether there is a limit to the extent to which BP should be lowered.
methodsFrom the individual 17 primary-prevention trials of single drug therapy included in a recent meta-analysis, we abstracted reductions in SBP (SBP reduction in the treatment group minus that in the control group [mmHg]) and data regarding incidence of stroke to generate relative risks (RRs). We performed "flexible" (not "linear") unrestricted maximum likelihood meta-regression, using fractional polynomials, of the reduction in SBP on the risk of stroke.
resultsThe best-fitting model offered a gain in deviance of 5.71 with respect to the reference linear model, according to the expected inverse J-shaped (nadir at a 13.7-mmHg reduction in SBP) dose-response relation between reductions in SBP and logarithmic RRs for stroke.
conclusionsMore than 13.7-mmHg SBP reduction with single drug therapy could produce no longer additional reduction in the risk of stroke in a primary-prevention setting.
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23702577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.