Evidence map›Paper›PMID 23702243›Full record

ReviewCurrent opinion in neurobiology2013

Sick and tired: how molecular regulators of human sleep schedules and duration impact immune function.

Philip A Kurien, S Y Christin Chong, Louis J Ptáček, Ying-Hui Fu

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. BHLHE41 suppresses MCF-7 cell invasion via MAPK/JNK pathway.Journal of cellular and molecular medicine · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Philip A KurienDepartment of Anesthesia, University of California San Francisco, San Francisco, CA 94143, United States.
S Y Christin Chong
Louis J Ptáček
Ying-Hui Fu
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
Comprehensive Anesthesia Research TrainingT32GM008440 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Judith Hellman · 1996 to 2026
$5.5M
GENETICS AND MOLECULAR CHARACTERIZATION OF ASPSR01HL059596 · NHLBI · UNIVERSITY OF UTAH · PI PTACEK, LOUIS J. · 1997 to 2012
$5.2M
Investigating Genetics of Human Natural Short SleepersR01NS072360 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2011 to 2015
$2.2M
A chemical genetic approach to dissect CKId & CKIe function in circadian rhythmR01GM079180 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2008 to 2011
$1.3M
Howard Hughes Medical InstituteNHLBI NIH HHS HL059596NHLBI NIH HHS R01 HL059596NIDDK NIH HHS P30 DK063720NIGMS NIH HHS GM079180NIGMS NIH HHS R01 GM079180NIGMS NIH HHS T32 GM008440NINDS NIH HHS NS072360NINDS NIH HHS R01 NS072360
6 · The paper itself

Abstract

Why do we need to sleep? What regulates when we sleep? And what dictates the number of hours we require? These are often viewed as three separate biological questions. Here, we propose they share molecular etiologies, whereby regulators of sleep schedules and sleep duration also govern the physiological purposes of sleep. To support our hypothesis, we review Mendelian human genetic variants sufficient to advance sleep-wake onset (PER2) and shorten sleep length (DEC2), and evaluate their emerging roles in immune responses that may rely on a sound night of slumber.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCircadian ClocksHumansPeriod Circadian ProteinsSleepBasic Helix-Loop-Helix ProteinsBHLHE41 protein, humanPER2 protein, humanPeriod Circadian Proteins

Identifiers

PMID23702243
PMCPMC3766463
OpenAlexW2041120008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.