Evidence map›Paper›PMID 23702180›Full record

ReviewClinics in chest medicine2013

Future directions: lung aging, inflammation, and human immunodeficiency virus.

Meghan Fitzpatrick, Kristina Crothers, Alison Morris

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in chest medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Alterations in Oral Microbiota in HIV Are Related to Decreased Pulmonary Function.American journal of respiratory and critical care medicine · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
    Article
  11. Article
  12. Article
  13. βAmerican journal of physiology. Lung cellular and molecular physiology · 2017
    Article
  14. Pulmonary Innate Immune Dysfunction in Human Immunodeficiency Virus.American journal of respiratory cell and molecular biology · 2017
    Review
  15. Article
  16. TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts.American journal of physiology. Cell physiology · 2015
    Article
  17. Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease.American journal of respiratory and critical care medicine · 2015
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Meghan FitzpatrickDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kristina Crothers
Alison Morris
University of Pittsburgh · USUniversity of Washington · US

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIVA, SRUTI · 2011 to 2020
$26.1M
Longitudinal Studies of HIV-Associated Lung Infections and ComplicationsR01HL090342 · NHLBI · YALE UNIVERSITY · PI CROTHERS, KRISTINA ANNE · 2007 to 2011
$4.0M
Prevalence & Pathogenesis of Pulmonary Disease in a Large Multicenter HIV CohortR01HL090339 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORRIS, ALISON · 2007 to 2011
$4.0M
Pathogenesis of Obstruction/Emphysema and the Microbiome (POEM) in HIVU01HL098962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GHEDIN, ELODIE, MORRIS, ALISON · 2009 to 2013
$3.8M
Role of Systemic and Pulmonary Immune Aging in HIV-associated COPDF32HL114426 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FITZPATRICK, MEGHAN E · 2012 to 2013
$126k
NHLBI NIH HHS F32 HL114426NHLBI NIH HHS F32HL114426NHLBI NIH HHS P01 HL103455NHLBI NIH HHS P01HL103455NHLBI NIH HHS R01 HL090339NHLBI NIH HHS R01HL090339NHLBI NIH HHS R01 HL090342NHLBI NIH HHS R01HL090342NHLBI NIH HHS U01 HL098962NHLBI NIH HHS U01HL098962
6 · The paper itself

Abstract

Chronic lung diseases, including chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), are unusually prevalent among persons infected with human immunodeficiency virus (HIV). Often these disease states are identified at younger ages than would be expected in the general population. Recent epidemiologic, basic scientific, and cross-sectional clinical data have implicated immune dysfunction and cellular senescence as potential drivers of advanced presentations of age-related diseases in HIV-infected persons. This article describes how HIV-associated COPD and PH may fit into a paradigm of immunosenescence, and outlines the hypothesized associations among chronic HIV infection, immune dysfunction and senescence, and cardiopulmonary outcomes.

Indexed as

Age of OnsetAgingHIVHIV InfectionsHumansHypertension, PulmonaryInflammationLungPulmonary Disease, Chronic Obstructive

Identifiers

PMID23702180
PMCPMC3659341
OpenAlexW16227375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.