ArticleBiomaterials2013
A multi-structural single cell model of force-induced interactions of cytoskeletal components.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- Article
- Discrete network models of endothelial cells and their interactions with the substrate.Biomechanics and modeling in mechanobiology · 2024Article
- Analysis of the Adherent Cell Response to the Substrate Stiffness Using Tensegrity.Annals of biomedical engineering · 2024Article
- Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The role of cellular traction forces in deciphering nuclear mechanics.Biomaterials research · 2022Review
- Finite element analysis of the influence of cyclic strain on cells anchored to substrates with varying properties.Medical & biological engineering & computing · 2022Article
- In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in the membrane for uniaxial substrate stretch.Medical & biological engineering & computing · 2021Article
- Finite element study of stem cells under fluid flow for mechanoregulation toward osteochondral cells.Journal of materials science. Materials in medicine · 2021Article
- Spatial correlation of cell stiffness and traction forces in cancer cells measured with combined SICM and TFM.RSC advances · 2021Article
- Evaluation of quasi-static and dynamic nanomechanical properties of bone-metastatic breast cancer cells using a nanoclay cancer testbed.Scientific reports · 2021Article
- Finite Element Simulations of Mechanical Behaviour of Endothelial Cells.BioMed research international · 2021Article
- Potential Molecular Players of the Tumor Microenvironment in Extracranial Pediatric Solid Tumors.Cancers · 2020Article
- Nonlinear Elastic and Inelastic Properties of Cells.Journal of biomechanical engineering · 2020Review
- Stress fiber anisotropy contributes to force-mode dependent chromatin stretching and gene upregulation in living cells.Nature communications · 2020Article
- Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics.International journal of molecular sciences · 2020Review
- A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Sensing and Modelling Mechanical Response in Large Deformation Indentation of Adherent Cell Using Atomic Force Microscopy.Sensors (Basel, Switzerland) · 2020Article
- Revealing hidden information in osteoblast's mechanotransduction through analysis of time patterns of critical events.BMC bioinformatics · 2020Article
- A NanoFE simulation-based surrogate machine learning model to predict mechanical functionality of protein networks from live confocal imaging.Computational and structural biotechnology journal · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Several computational models based on experimental techniques and theories have been proposed to describe cytoskeleton (CSK) mechanics. Tensegrity is a prominent model for force generation, but it cannot predict mechanics of individual CSK components, nor explain the discrepancies from the different single cell stimulating techniques studies combined with cytoskeleton-disruptors. A new numerical concept that defines a multi-structural 3D finite element (FE) model of a single-adherent cell is proposed to investigate the biophysical and biochemical differences of the mechanical role of each cytoskeleton component under loading. The model includes prestressed actin bundles and microtubule within cytoplasm and nucleus surrounded by the actin cortex. We performed numerical simulations of atomic force microscopy (AFM) experiments by subjecting the cell model to compressive loads. The numerical role of the CSK components was corroborated with AFM force measurements on U2OS-osteosarcoma cells and NIH-3T3 fibroblasts exposed to different cytoskeleton-disrupting drugs. Computational simulation showed that actin cortex and microtubules are the major components targeted in resisting compression. This is a new numerical tool that explains the specific role of the cortex and overcomes the difficulty of isolating this component from other networks in vitro. This illustrates that a combination of cytoskeletal structures with their own properties is necessary for a complete description of cellular mechanics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.