Evidence map›Paper›PMID 23702145›Full record

ArticleCurrent opinion in cell biology2013

COPII - a flexible vesicle formation system.

Elizabeth A Miller, Randy Schekman

Abstract read
In one paragraph

Article in Current opinion in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Collagen IV biosynthesis: Intracellular choreography of post-translational modifications.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Tailored assemblies of COPII proteins in secretion.The Journal of cell biology · 2024
    Review
  18. Review
  19. Trafficking of Connexin36 (Cx36) in the early secretory pathway.bioRxiv : the preprint server for biology · 2024
    Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elizabeth A MillerDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA. em2282@columbia.edu
Randy Schekman

Funding

ER export and the quality control checkpoint during membrane protein biogenesisR01GM078186 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BULINSKI, JEANNETTE CHLOE, MILLER, ELIZABETH A. · 2006 to 2015
$2.7M
Molecular mechanisms of cargo capture into ER-derived transport vesiclesR01GM085089 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BULINSKI, JEANNETTE CHLOE, MILLER, ELIZABETH A. · 2008 to 2016
$2.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM078186NIGMS NIH HHS R01GM078186NIGMS NIH HHS R01 GM085089NIGMS NIH HHS R01GM085089
6 · The paper itself

Abstract

Long known as a coat system that generates small transport vesicles from the endoplasmic reticulum (ER), the COPII coat also drives ER export of cargo proteins that are too large to be contained within these canonical carriers. With crystal and cryo-EM structures giving an atomic level view of coat architecture, current advances in the field have focused on understanding how the coat adapts to the different geometries of the underlying cargo. Combined with a growing appreciation for the specific roles of individual COPII paralogs in diverse aspects of mammalian physiology, the field is poised to understand how coat assembly and post-translational modification permits structural rigidity but geometric flexibility to handle the diverse cargoes that exit the ER.

Indexed as

Protein TransportAnimalsCOP-Coated VesiclesEndoplasmic ReticulumHumansProtein Processing, Post-TranslationalSecretory PathwayYeasts

Identifiers

PMID23702145
PMCPMC3736695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.