Trial reportTrials2013
Transfusion requirements in septic shock (TRISS) trial - comparing the effects and safety of liberal versus restrictive red blood cell transfusion in septic shock patients in the ICU: protocol for a randomised controlled trial.
Trial report in Trials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Red Blood Cell Transfusion on Mortality and Morbidity in Patients With Septic Shock
Restrictive Versus Liberal Thresholds for Red Blood Cell Transfusion in ExtraCorporeal Membrane Oxygenation - the TREC Study
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Long-term outcomes in patients with septic shock transfused at a lower versus a higher haemoglobin threshold: the TRISS randomised, multicentre clinical trial.Intensive care medicine · 2016Trial
- Jehovah's Witness Needing Critical Care: A Narrative Review on the Expanding Arsenal.Critical care research and practice · 2024Review
- Appropriateness of Allogeneic Red Blood Cell Transfusions in Non-Bleeding Patients in a Large Teaching Hospital: A Retrospective Study.Journal of clinical medicine · 2023Article
- Racial differences in red blood cell transfusion in hospitalized patients with anemia.Transfusion · 2022Article
- A Physiologic Approach to Hemodynamic Monitoring and Optimizing Oxygen Delivery in Shock Resuscitation.Journal of clinical medicine · 2020Review
- Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit-a prospective observational study in the intensive care unit.Critical care (London, England) · 2020Observational
- The effect of red-blood-cell transfusion on fatigue in hospitalized patients with anaemia.Vox sanguinis · 2018Observational
- Comment on Debate: Blood is Friend or/and Foe?Turkish journal of anaesthesiology and reanimation · 2018Article
- Association Between Anemia and Fatigue in Hospitalized Patients: Does the Measure of Anemia Matter?Journal of hospital medicine · 2017Article
- [International guidelines from the Surviving Sepsis Campaign : 2016 update].Der Anaesthesist · 2017Review
- Blood Transfusions Correct Anemia and Improve Tissue Oxygenation in Surgical and Critically ill Patients.Turkish journal of anaesthesiology and reanimation · 2017Article
- Daily Lowest Hemoglobin and Risk of Organ Dysfunctions in Critically Ill Patients.Critical care medicine · 2017Article
- Getting down to the real question: effects of transfusion triggers on long-term survival and quality of life following septic shock.Intensive care medicine · 2016Article
- Observational
- Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics.Shock (Augusta, Ga.) · 2015Article
- Testing current practice is no mistake.Intensive care medicine · 2015Article
- Effect of ERK1/2 signaling pathway in electro-acupuncture mediated up-regulation of heme oxygenase-1 in lungs of rabbits with endotoxic shock.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Red blood cell transfusion in septic shock - clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort.Scandinavian journal of trauma, resuscitation and emergency medicine · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 20 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransfusion of red blood cells (RBC) is recommended in septic shock and the majority of these patients receive RBC transfusion in the intensive care unit (ICU). However, benefit and harm of RBCs have not been established in this group of high-risk patients. METHODS/
designThe Transfusion Requirements in Septic Shock (TRISS) trial is a multicenter trial with assessor-blinded outcome assessment, randomising 1,000 patients with septic shock in 30 Scandinavian ICUs to receive transfusion with pre-storage leuko-depleted RBC suspended in saline-adenine-glucose and mannitol (SAGM) at haemoglobin level (Hb) of 7 g/dl or 9 g/dl, stratified by the presence of haematological malignancy and centre. The primary outcome measure is 90-day mortality. Secondary outcome measures are organ failure, ischaemic events, severe adverse reactions (SARs: anaphylactic reaction, acute haemolytic reaction and transfusion-related circulatory overload, and acute lung injury) and mortality at 28 days, 6 months and 1 year.The sample size will enable us to detect a 9% absolute difference in 90-day mortality assuming a 45% event rate with a type 1 error rate of 5% and power of 80%. An interim analysis will be performed after 500 patients, and the Data Monitoring and Safety Committee will recommend the trial be stopped if a group difference in 90-day mortality with P ≤0.001 is present at this point. DISCUSSION: The TRISS trial may bridge the gap between clinical practice and the lack of efficacy and safety data on RBC transfusion in septic shock patients. The effect of restrictive versus liberal RBC transfusion strategy on mortality, organ failure, ischaemic events and SARs will be evaluated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.