ArticleBMC infectious diseases2013
Assessment of motivating factors associated with the initiation and completion of treatment for chronic hepatitis C virus (HCV) infection.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02707991 (Nurse Case Management to Improve Linkage to Hepatitis C Care and Treatment Initiation in HIV Co-infection), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nurse Case Management to Improve Linkage to Hepatitis C Care and Treatment Initiation in HIV Co-infection: A Randomized Controlled Trial
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Meta-Analysis of Combination Therapy of Chinese Herbs Plus Interferon and Ribavirin in Patients with Chronic Hepatitis C.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Care2Cure: A randomized controlled trial protocol for evaluating nurse case management to improve the hepatitis C care continuum within HIV primary care.Research in nursing & health · 2018Trial
- Illness perception about hepatitis C virus infection: a cross-sectional study from Khyber Pakhtunkhwa Pakistan.BMC infectious diseases · 2022Article
- Adoption of direct-acting antiviral medications for hepatitis C: a retrospective observational study.BMC health services research · 2019Observational
- Engagement in Care of High-Risk Hepatitis C Patients with Interferon-Free Direct-Acting Antiviral Therapies.Digestive diseases and sciences · 2017Article
- Does Hepatitis C Treatment Adherence Affect Risk of Liver Transplantation? A Historical Cohort Study.Journal of managed care & specialty pharmacy · 2016Observational
- The Australasian Hepatology Association consensus guidelines for the provision of adherence support to patients with hepatitis C on direct acting antivirals.Patient preference and adherence · 2016Article
- Results from a Geographically Focused, Community-Based HCV Screening, Linkage-to-Care and Patient Navigation Program.Journal of general internal medicine · 2015Article
- Utility of evaluating HCV in an uninsured population.Digestive diseases and sciences · 2015Article
- "Test, Listen, Cure" (TLC) Hepatitis C Community Awareness Campaign.JMIR research protocols · 2015Article
- Clinical Applications of Quantitative Real-Time PCR in Virology.Methods in microbiology · 2015Article
- "Fighting an uphill battle": experience with the HCV triple therapy: a qualitative thematic analysis.BMC infectious diseases · 2014Article
- Patient Characteristics, Safety, and Tolerability with Telaprevir Treatment for HCV in the Clinic: a Retrospective, Multicenter Study.Journal of clinical and translational hepatology · 2014Article
- How to study determinants related to medication adherence in newly diagnosed polyarthritis patients for the development of a prediction instrument.Patient preference and adherence · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection with hepatitis C virus (HCV) is associated with high morbidity and increased mortality but many patients avoid initiation of treatment or report challenges with treatment completion. The study objective was to identify motivators and barriers for treatment initiation and completion in a community sample of HCV-infected patients in the United States.
methodsSurvey methods were employed to identify factors reported by patients as important in their decision to start or complete HCV treatment. Study participants included 120 HCV-infected individuals: 30 had previously completed treatment with pegylated interferon/ribavirin (PR), 30 had discontinued PR, 30 were treated with PR at the time of the survey, and 30 were treatment‒naïve. Telephone interviews occurred between May and August of 2011 and employed a standardized guide. Participants assigned factors a rating from 1 (not at all important) to 5 (extremely important). Trained researchers coded and analyzed interview transcripts.
resultsOf 33 factors, expected health problems from not treating HCV infection was reported as most encouraging for treatment initiation and completion, while treatment side effects was most discouraging. Sixty-nine percent of participants reported that the ability to obtain information during treatment on the likelihood of treatment success (i.e., results of viral load testing) would motivate them to initiate therapy. Median preferred timing for learning about test results was 5 weeks (range: 1-23 weeks).
conclusionUnderstanding challenges and expectations from patients is important in identifying opportunities for education to optimize patient adherence to their HCV treatment regimen.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.