ReviewSeminars in cell & developmental biology
The mortal strand hypothesis: non-random chromosome inheritance and the biased segregation of damaged DNA.
Review in Seminars in cell & developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Role of Diet in Stem and Cancer Stem Cells.International journal of molecular sciences · 2022Review
- Nuclear movement in fungi.Seminars in cell & developmental biology · 2018Review
- Cell cycle arrest in plants: what distinguishes quiescence, dormancy and differentiated G1?Annals of botany · 2017Review
- Hematopoietic Stem Cells: Uncomfortable Considerations.Current molecular biology reports · 2017Article
- Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions.Nucleic acids research · 2015Review
- Just like the rest of evolution in Mother Nature, the evolution of cancers may be driven by natural selection, and not by haphazard mutations.Oncoscience · 2014Article
- DNA asymmetry in stem cells - immortal or mortal?Journal of cell science · 2013Review
- A Novel Class of Human Cardiac Stem Cells.Cardiology in reviewArticle
Corrections and comments
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Authors and funding
2 authors.
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Abstract
If a eukaryotic cell is to reproduce, it must duplicate its genetic information in the form of DNA, and faithfully segregate that information during a complex process of cell division. During this division process, the resulting cells inherit one, and only one, copy of each chromosome. Over thirty years ago, it was predicted that the segregation of sister chromosomes could occur non-randomly, such that a daughter cell would preferentially inherit one of the two sister chromosomes according to some characteristic of that chromosome's template DNA strand. Although this prediction has been confirmed in studies of various cell-types, we know little of both the mechanism by which the asymmetric inheritance occurs and the significance it has to cells. In this essay, we propose a new model of non-random chromosome segregation-the mortal strand hypothesis-and discuss tests of the model that will provide insight into the molecular choreography of this intriguing phenomenon.
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Registered trials
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