ArticleJournal of proteome research2013
Microbial-mammalian cometabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American populations.
Article in Journal of proteome research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children.Scientific reports · 2016Trial
- Urinary metabolic age from high-resolution nuclear magnetic resonance spectroscopy reveals longitudinal aging patterns.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Comprehensive age-specific metabolic phenotyping in myocardial infarction.BMC cardiovascular disorders · 2026Article
- Host-microbial co-metabolites: from biogenesis to immunomodulation and implications for health and disease.Frontiers in immunology · 2026Review
- Investigating a Systematic and Widespread Misidentification in the Metabolic Profiling Literature: Phenylacetylglutamine and Phenylacetylglycine Signal Misassignment in Proton NMR Spectra of Human and Rodent Urine.Analytical chemistry · 2025Article
- Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson's disease.Molecular neurodegeneration · 2023Article
- Fractures in sub-Saharan Africa: epidemiology, economic impact and ethnography (Fractures-EWellcome open research · 2023Article
- The metabolomics of human aging: Advances, challenges, and opportunities.Science advances · 2022Review
- Utilization of Host and Microbiome Features in Determination of Biological Aging.Microorganisms · 2022Review
- Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency.RSC advances · 2021Article
- Metabolomics Signatures of Aging: Recent Advances.Aging and disease · 2021Review
- Gut-Derived Metabolite Phenylacetylglutamine and White Matter Hyperintensities in Patients With Acute Ischemic Stroke.Frontiers in aging neuroscience · 2021Article
- Considerations for the design and conduct of human gut microbiota intervention studies relating to foods.European journal of nutrition · 2020Review
- Review
- Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China.JAMA network open · 2019Article
- Modelling the role of microbial p-cresol in colorectal genotoxicity.Gut microbes · 2019Article
- Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry and Direct Infusion-High-Resolution Mass Spectrometry for Combined Exploratory and Targeted Metabolic Profiling of Human Urine.Journal of proteome research · 2018Article
- Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease.Frontiers in aging neuroscience · 2018Article
- Article
- NMR-based metabolomic profiling of overweight adolescents: an elucidation of the effects of inter-/intraindividual differences, gender, and pubertal development.BioMed research international · 2014Article
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
Understanding the metabolic processes associated with aging is key to developing effective management and treatment strategies for age-related diseases. We investigated the metabolic profiles associated with age in a Taiwanese and an American population. ¹H NMR spectral profiles were generated for urine specimens collected from the Taiwanese Social Environment and Biomarkers of Aging Study (SEBAS; n = 857; age 54-91 years) and the Mid-Life in the USA study (MIDUS II; n = 1148; age 35-86 years). Multivariate and univariate linear projection methods revealed some common age-related characteristics in urinary metabolite profiles in the American and Taiwanese populations, as well as some distinctive features. In both cases, two metabolites--4-cresyl sulfate (4CS) and phenylacetylglutamine (PAG)--were positively associated with age. In addition, creatine and β-hydroxy-β-methylbutyrate (HMB) were negatively correlated with age in both populations (p < 4 × 10⁻⁶). These age-associated gradients in creatine and HMB reflect decreasing muscle mass with age. The systematic increase in PAG and 4CS was confirmed using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). Both are products of concerted microbial-mammalian host cometabolism and indicate an age-related association with the balance of host-microbiome metabolism.
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Registered trials
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